Grains - The Real Cereal Killer

By Dr. Mercola

The persistent myth that dietary fat causes obesity and promotes heart disease has undoubtedly ruined the health of millions of people. It's difficult to know just how many people have succumbed to chronic poor health from following conventional low-fat, high-carb recommendations, but I'm sure the number is significant.

In the featured documentary, Cereal Killers, 41-year-old Donald O'Neill turns the American food pyramid upside-down—eliminating sugars and grains, and dramatically boosting his fat intake. In so doing, he improves his health to the point of reducing his hereditary risk factors for heart disease to nil.

Watching people's reactions to his diet brings home just how brainwashed we've all become when it comes to dietary fat. Most fear it. Yet they will consume sugar in amounts that virtually guarantee they'll suffer all the devastating health consequences they're trying to prevent by avoiding fat, and then some!

Fat versus Carbs—What Really Makes You Pack on the Pounds?

The fact is, you've been thoroughly misled when it comes to conventional dietary advice. Most dietary guidelines have been massively distorted, manipulated, and influenced by the very industries responsible for the obesity epidemic in the first place—the sugar and processed food industries.

Shunning the evidence, many doctors, nutritionists, and government health officials will still tell you to keep your saturated fat below 10 percent, while keeping the bulk of your diet, about 60 percent, as carbs.1 This is madness, as it's the converse of a diet that will lead to optimal health.

A recent Time Magazine2 article highlighted a report by the Environmental Working Group (EWG), which showed that many breakfast cereals contain more than 50 percent sugar by weight! Cereals marketed specifically to children are among the worst offenders. Kellogg's Honey Smacks and Mom's Best Cereals Honey-Ful Wheat topped the list with 56 percent sugar by weight. If you're looking for alternatives for your family you could try Snackimals from Barbara's. Snackimals is not on the EWG's list because it is a newer product. All of their flavors have only 7 grams of sugar per serving.

Even diabetes organizations promote carbohydrates as a major component of a healthy diet—even though grains break down to sugar in your body, and sugar promotes insulin resistance, which is the root cause of type 2 diabetes in the first place.

As noted in the film: "If we could get all diabetics to eat a high-fat, high-protein, low-carbohydrate diet, we would cut the insulin requirement so dramatically that it's been estimated that six pharmaceutical companies would go out of business tomorrow."Contrary to popular belief, you do not get fat from eating fat. You get fat from eating too much sugar and grains.

Refined carbohydrates promote chronic inflammation in your body, elevate low-density LDL cholesterol, and ultimately lead to insulin and leptin resistance. Insulin and leptin resistance, in turn, is at the heart of obesity and most chronic disease, including diabetes, heart disease, cancer, and Alzheimer's—all the top killers in the US. 

Don't Fear the Fat

In the film, O'Neill switches over to a diet where 70 percent of his calories come from healthy fat—most of it in the form of macadamia nuts (my personal favorite)—and the remaining 30 percent of his caloric intake is divvied up between protein and fibrous fruits and vegetables. Over the course of 28 days, O'Neill:

• Loses weight and body fat
• Increases his lean muscle mass
• Feels more energetic and improves his athletic performance
• Increases his resting metabolic rate
• Improves his blood pressure, cholesterol, and other measurements to the point that he no longer has any risk factors for heart disease, which he's genetically predisposed for

Of particular importance here is that O'Neill's total cholesterol and LDL levels wentup, which initially caused significant concern. However, once they tested the LDL particle numbers, the results showed that his LDL particles were the largest species known, and he had virtually no small LDL particles at all.

This is phenomenal, as it's the small, dense LDL particles that cause inflammation. Large particles do not. Also, the markers for inflammation were virtually nonexistent, showing that he has no inflammation in his body at all. All in all, his one-month long high-fat, no-carb diet experiment proved that:

• Eating fat helps you lose fat
• Eating saturated fat decreases your risk factors for heart disease
• Regardless of your genetic predisposition your diet is, ultimately, the determining factor

I would also add that his results show the benefits of a high-fat, low-carb diet for athletes, many of whom are still convinced that this type of diet will make them heavy and sluggish. On the contrary, O'Neill breaks his own athletic record during his experiment, and refers to his renewed sense of vigor as feeling like a "spring lamb."

This high and sustained energy is a hallmark of ketogenesis, where your body is burning fat rather than sugar as its primary fuel. When your body burns fat, you don't experience the energy crashes associated with carbs.

Saturated Fat and Cholesterol Are Both Necessary for Optimal Health

Contrary to popular belief, saturated fats from animal and vegetable sources provide a number of important health benefits, and your body requires them for the proper function of your:

Cholesterol—another wrongly vilified dietary component—also carries out essential functions within your cell membranes, and is critical for proper brain function and production of steroid hormones, including your sex hormones. Vitamin D is also synthesized from a close relative of cholesterol: 7-dehydrocholesterol. 

Your body is composed of trillions of cells that need to interact with one another. Cholesterol is one of the molecules that allow for these interactions to take place. For example, cholesterol is the precursor to bile acids, so without sufficient amounts of cholesterol, your digestive system can be adversely affected. It's also critical for synapse formation in your brain, i.e. the connections between your neurons, which allow you to think, learn new things, and form memories. In fact, there's reason to believe that low-fat diets and/or cholesterol-lowering drugs may cause or contribute to Alzheimer's disease.3

Replacing Refined Carbs with Healthy Fat—The Answer to Most of Your Health Concerns

Underlying most chronic diseases, including obesity, type 2 diabetes, heart disease, and cancer are inflammation and insulin/leptin resistance. When you eat carbohydrates, your blood sugar, insulin, and leptin will all temporarily rise, and these spikes are very pro-inflammatory. Where you have inflammation, disease and dysfunction follows. An excellent editorial in the journal Open Heart4 reviews the cardiometabolic consequences of replacing saturated fats with carbohydrates, which includes the following:

The answer, then, lies in avoiding these inflammatory spikes in blood sugar, insulin and leptin, and reversing insulin and leptin resistance. To do this, you need to:

• Avoid refined sugar, processed fructose, and grains. This means avoiding processed foods, as they are chockfull of these ingredients, along with other chemicals that can wreak metabolic havoc
• Eat a healthful diet of whole foods, ideally organic, and replace the grain carbs you cut out with:
• Moderate amounts of high-quality protein from organic, grass-fed or pastured animals (this is to ensure you're not getting the antibiotics, genetically engineered organisms, and altered nutritional fat profile associated with factory farmed animals)
• High amounts of high-quality healthful fat as you want (saturated and monounsaturated). Many health experts now believe that if you are insulin or leptin resistant, as 85 percent of the US population is, you likely need anywhere from 50 to 85 percent of your daily calories in the form of healthful fats for optimal health. Good sources include coconut and coconut oil, avocados, butter, nuts (particularly macadamia), and animal fats. Avoid all trans fats and processed vegetable oils (such as canola and soy oil). Also take a high-quality source of animal-based omega-3 fat, such as krill oil.
• As many vegetables as you can muster. Juicing your vegetables is a good way to boost your vegetable intake

Another "add-on" suggestion is to start intermittent fasting, which will radically improve your ability to burn fat as your primary fuel. This too will help restore optimal insulin and leptin signaling.

What's the Deal with Protein?

Dr. Rosedale, who was one of my primary mentors on the importance of insulin and leptin, was one of the first professionals to advocate both a low-carb and moderate protein (and therefore high-fat) diet. This was contrary to most low-carb advocates who were, and still are, very accepting of using protein as a replacement for the carbs.

The problem is that, along with grains, most Americans tend to eat far too much protein. While your body certainly has a protein requirement, there's evidence suggesting that eating more protein than your body needs could end up fueling cancer growth.

Dr. Rosedale advises limiting your protein to one gram of protein per kilogram of lean body mass (or 0.5 grams per pound of lean body weight). For most people, this means cutting protein down to about 35-75 grams per day. Pregnant women and those working out extensively need about 25 percent more. I believe this theory is worthy of consideration. The key though is to add healthy fat to replace the carb and protein calories you're cutting out of your diet. Again, sources of healthy fat include:

Your Health Is Within Your Control

Groundbreaking research by the likes of Dr. Robert Lustig and Dr. Richard Johnson (author of the books, The Sugar Fix and The Fat Switch) clearly identifies the root cause of obesity, diabetes, heart disease, and numerous other chronic diseases, and it's notfat. It's refined sugar—particularly fructose—consumed in excessive amounts. Their research, and that of others, provides us with a clear solution to our current predicament. In short, if you want to normalize your weight and protect your health, you need to address your insulin and leptin resistance, which is the result of eating a diet too high in sugars and grains.

For a comprehensive guide, see my free optimized nutrition plan. Generally speaking though, you'll want to focus your diet on whole, ideally organic, unprocessed or minimally processed foods. For the best nutrition and health benefits, you'll also want to eat a good portion of your food raw.

Sugar is highly addictive, and if you're like most people, you're no stranger to carb cravings. Just know that once your body gets used to burning fat instead of sugar as its primary fuel, those cravings will vanish. Many cereals and other grain products would not be quite as harmful if they didn't also contain so much added sugar. Even many organic brands contain excessive amounts. This is unfortunate, since many (Americans in particular) are really indoctrinated to eat cereal for breakfast. I've been working on a low-sugar cereal line for some time now, to provide a healthier alternative for those who really don't want to give up their breakfast cereal. I hope to have it ready sometime this summer.

Last but not least, for those of you still concerned about your cholesterol levels, know that 75 percent of your cholesterol is produced by your liver, which is influenced by your insulin levels. Therefore, if you optimize your insulin level, you will automatically optimize your cholesterol, thereby reducing your risk of both diabetes and heart disease.

Also, remember that even if a high-fat, low-carb diet was to raise your total cholesterol and LDL, it doesn't automatically mean that your diet is increasing your risk factors for heart disease. As O'Neill did in this film, you need to test your LDL particle number. Large-sized particles are good, while the smaller, denser particles can penetrate the lining of your arteries and stimulate the plaque formation associated with heart disease. The former does NOT increase your heart disease risk, while the latter one will. To learn more about LDL particle numbers and how to test them, please see my previous interview with Chris Kresser, L.Ac., which goes into this in some detail.

• 1 US Department of Agriculture, Dietary Guidelines for Americans 2010 (PDF)
• 2 Time May 15, 2014
• 3 Stephanie Seneff, APOE-4: The Clue to Why Low Fat Diet and Statins may Cause Alzheimer's
• 4 Open Heart March 5, 2014

Too Much Protein??

Media sources often report, “too much protein stresses the kidney.” What does science say? Martin and colleagues reviewed the available evidence regarding the effects of protein intake on kidney function with a particular emphasis on kidney disease. The researchers found: “Although excessive protein intake remains a health concern in individuals with preexisting renal disease, the literature lacks significant research demonstrating a link between protein intake and the initiation or progression of renal disease in healthy individuals.” In addition “At present, there is not sufficient proof to warrant public health directives aimed at restricting dietary protein intake in healthy adults for the purpose of preserving renal function.” Protein restriction is common treatment for people with kidney problems.

Protein: The Facts, the Myths, and the Real Science

Everyone has an opinion about protein, and the myths surrounding it are rampant. That's why sorting the facts from the crap will lead to better choices regarding your own diet and protein intake. Answer the questions below and see if you've been falling for the myths.

Fact or Myth?

The RDA (Recommended Dietary Allowance) protein suggestions are just fine for people who work out.

Hint: The RDA guideline for protein is 0.8 grams per kilogram of bodyweight per day. So if you weigh 190 pounds (86 kilograms) you'd need about 69 grams of protein.

The Answer: Lifters and athletes concerned with their performance or physique require more protein than what's recommended by the RDA. So it's a myth (and a joke) that the RDA protein recommendations are adequate for ass-kicking individuals.

Here's Why: RDA protein recommendations are too low for certain groups. Those recommendations were never intended for people attempting to enhance performance, maintain, or gain muscle. In fact, a higher protein intake may have positive benefits regarding different health ailments including obesity, type 2 diabetes, osteoporosis, heart disease and muscle wasting.

The RDA guideline reflects the minimum daily needs of protein required to maintain short-term nitrogen balance in healthy, moderately active people. Nitrogen balance compares the amount of nitrogen coming into the body (from dietary protein) to the amount being lost. It's often used as a measurement of protein balance since protein is 16 percent nitrogen.

If you're consuming the same amount of nitrogen that you're losing, you're in nitrogen balance. If you're consuming more than you're losing, you're in positive nitrogen balance. If you're losing more than you're consuming, you're in negative nitrogen balance and are losing protein.

Nitrogen balance studies often involve examining urinary nitrogen levels. Approximately 90 percent of the nitrogen in urine is urea and ammonia salts – the end products of protein metabolism. The remaining nitrogen is accounted for by other nitrogen-containing compounds.

This nitrogen balance method is useful, but it has problems: Urine collections tend to underestimate nitrogen losses, dietary intake tends to be overestimated, miscellaneous skin and hair losses are prone to error, and the response to increased protein intake varies tremendously.

The Really Geeky Stuff

1. In a review published in the International Journal of Sports Nutrition, researchers concluded, "Those involved in strength training might need to consume as much as 1.6 to 1.7 grams of protein per kilogram per day (approximately twice the current RDA) while those undergoing endurance training might need about 1.2 to 1.6 grams per kilogram per day (approximately 1.5 times the current RDA)."
2. In another article published in Nutrition & Metabolism, researcher Donald Layman argued that the dietary guidelines should be improved and reflect new understandings about protein requirements. According to him, "During the past decade a growing body of research reveals that dietary protein intakes above the RDA are beneficial in maintaining muscle function and mobility." Diets with increased protein have been shown to improve adult health when it comes to treatment or prevention of obesity, type 2 diabetes, osteoporosis, heart disease and muscle wasting.
3. A review published in the International Journal of Sport Nutrition and Exercise Metabolism was conducted to evaluate the effects of dietary protein on body composition in energy-restricted resistance-trained athletes, and to provide protein recommendations for these athletes.

The researchers concluded that "...the range of 2.3 to 3.1 grams per kilogram of FFM (fat free mass) is the most consistently protective intake against losses of lean tissue." In other words, for every kilogram on your body that's not fat, you should be consuming 2-3 grams of protein in order to preserve lean tissue. So if you have 190 pounds of lean tissue, up to 258 grams of protein would be optimal for you.

In addition, the goal of the athlete should be considered. Leaner athletes or those having a primary goal of maintaining maximal FFM should aim toward intakes approaching the higher end of this range. Even higher levels of protein than those recommended in the review are not uncommon in exercising individuals. It's unlikely that negative health consequences will follow from higher levels of intake, assuming there are no related health problems that would suggest limiting intake.

Fact or Myth?

The thermic effect of protein is the same as it is for carbs and fat.

Hint: The thermic effect of feeding or diet induced thermogenesis (DIT) is the amount of energy your body has to expend in order to digest and assimilate food. So picture a lean chicken breast (mostly protein), a bowl of rice (mostly carb), and tablespoon of butter (mostly fat). Which do you think your body will have to work hardest to digest?

The Answer: Among the three macronutrients, protein ranks highest in diet induced thermogenesis. So it's a myth that they're all equal in terms of their thermic effect. That means it'll cost you more calories to digest and absorb protein than it would fat and carbohydrate.

Here's Why: The consumption of protein requires an expenditure of 20-30% of the calories derived from protein. So, if 200 calories of protein are eaten, 40-60 calories are burned during digestion. DIT from carbohydrate is 15-20% and 2-5% for fat.

Fact or Myth?

Protein is more satiating (filling) than fat or carbohydrate.

Hints: Protein has an influence on CCK (cholecystokinin) and ghrelin. Protein may stimulate cholecystokinin (CCK) and decrease ghrelin. CCK is secreted mostly from the inner layer of the gastrointestinal tract has been shown to act as a satiety signal. The satiating effect of CCK was first demonstrated when administering CCK to rats. It "dose dependently" reduced meal size. Ghrelin is produced primarily in the stomach and has appetite increasing properties. Ghrelin levels are relatively high prior to a meal and they decrease after a meal.

The Answer: It's a fact that protein is usually more satiating than fat or carbs. When comparing protein, fat, and carbohydrate, protein is generally reported as the most satiating (satisfying to a point of full or beyond) and fat as the least satiating.

Here's Why: Research indicates that one of the primary factors involved with the satiating effects of protein is the thermic effect of feeding, mentioned above. Though protein's influence on ghrelin and CCK may play a large role in its satiating effects, more research needs to be conducted in these areas, as findings have been indecisive. Future research should concentrate on different levels of protein, different types of protein, and consumption of proteins in short and long term.

The Really Geeky Stuff

1. A review published in Nutrition & Metabolism reported that protein induced thermogenesis has an important effect on satiety. "Protein plays a key role in body weight regulation through satiety related to diet-induced thermogenesis."
2. A study published in Physiology & Behavior investigated the relative satiating effect of the macronutrients in lean women. On four separate occasions, the composition of an iso-caloric lunch "preload" was controlled in 12 lean women. Macronutrient composition had a significant effect on short-term hunger – the women were less hungry after the protein preload compared to the preloads with the other macronutrients. They also ate less after the protein preload.
3. A study published in the American Journal of Clinical Nutrition tested the prediction that increasing protein while maintaining the carb content of a diet lowers body weight due to decreased appetite and decreased calorie intake. The study showed when increasing the protein intake from 15% of diet to 30% of diet (while eating the same amount of carbs) there was a decrease in appetite and fewer calories were consumed.
4. The Journal of Clinical Endocrinology & Metabolism published a study that compared the effect of different proteins and carbohydrates on indicators of appetite and appetite regulatory hormones. CCK level was one of the primary outcomes measured.

Calorie intake was higher after the glucose preload compared with lactose and protein preloads. CCK level was higher 90 minutes after the protein preloads compared with glucose and lactose level. Researchers concluded that "acute appetite and energy intake are equally reduced after consumption of lactose, casein, or whey compared with glucose."

One Quick Caveat

The research sometimes gets a little messy. For example, some studies are indecisive when it comes to protein intake and ghrelin levels. This is why you need to rely on your own reasoning, logic, and experience while gathering info from the research.

References

1. Blom, A.M., Lluch, A., Stafleu, A., Vinoy, S., Holst, J., Schaafsma, G., & Hendriks, H. (2006). Effect of high-protein breakfast ont he postprandial ghrelin response. The American Journal of Clinical Nutrition, 83(2), 211-220.
2. Bowen, J., Noakes, M., Trenerry, C., & Clifton, P.M. (2006).Energy intake, Ghrelin, and Cholecystokinin after Different Carbohydrate and Protein Preloads in Overweight Men. The Journal of Clinical Endocrinology & Metabolism, 91(4).
3. Helms, E., Zinn, C., Rowlands, D.S., & Brown, S.R. (2014). A Systematic Review of Dietary Protein During Caloric Restriction in Resistance Trained Lean Athletes: A Case for Higher Intakes. International Journal of Sport Nutrition and Exercise Metabolism, 24, 127-138.
4. Layman, D.K.(2009). Dietary Guidelines should reflect new understandings about adult protein needs. Nutrition & Metabolism, 6(12), Lemon, P. (1998). Effects of exercise on dietary protein requirements. International Journal of Sports Nutrition, 8(4), 426-447.
5. Lucas, M, & Heiss C.J.(2005) Protein needs of older adults engaged in resistance training: A review. Journal of Aging and Physical Activity, 13(2), 223-236.
6. Moran, L.J., Luscombe-Marsh, N.D., Noakes, M., Wittert, G.A., Keogh, J.B., & Clifton, P.M. (2005). The Satiating Effect of Dietary Protein Is Unrelated to Postprandial Ghrelin. The Journal of Clinical Endocrinology & Metabolsim, 90(9).
7. Poppitt, S.D., McCormack, D., & Buffenstein, R. (1998).Short-term effects of macronutrient preloads on appetite and energy intake in lean women. Physiology & Behavior, 64(3), 279-285.
8. Weigle, D.S., Breen, P.A., Matthys, C.C., Callahan, H.S., Meeuws, K.E., Burden, V.R., & Purnell, J.Q. (2005). A high-protein diet induces sustained reductions in appetite, ad libitum caloric intake, and body weight despite compensatory changes in diurnal plasma leptin and ghrelin concentrations. The American Journal of Clinical Nutrition, 82(1), 41-48.
9. Westerterp, K.R. (2004). Diet induced thermogenesis. Nutrition & Metabolism, 1, 1-5

What Enzymes Does Mercury Inhibit?

Mercury is a heavy metal that has been used for centuries as a medicine and a poison. Common exposures come from contaminated seafood, dental amalgams, and vaccines for infants. Mercury can exist in 11 different chemical states or compounds. At the molecular level, it forms bonds with sulfhydryl groups on an enzyme, which are parts of the enzyme that contain a sulfur atom that is attached to a hydrogen atom (SH). Binding of mercury can change the shape of the enzyme and block its activity. Enzymes inhibited by mercury include acetylcholinesterase, catalase, dipeptyl peptidase (CD26), amylase, lipase, lactase and glucose-6-phosphatase.

Acetylcholinesterase

Acetylcholine is one of the main neurotransmitters that nerves use to control muscle movement. After release, acetylcholine must be degraded in order to stop the “go” signal from continuing to stimulate the receiving cell. Acetylcholine is degraded by an enzyme called acetylcholinesterase. This enzyme is found in the synaptic cleft, which is the space between the "fingertips" of a nerve cell and the neighboring cell that the nerve activates. Mercury inhibits this enzyme differently in different species, depending on whether it can easily find a sulfhydryl group to latch onto. For human acetylcholinesterase, it takes millimolar amounts of mercuric chloride (HgCl2) to inhibit the enzyme.

Catalase

Catalase is an enzyme that converts hydrogen peroxide into water and oxygen. Hydrogen peroxide is regularly produced by cells as they make energy in a process called cellular respiration. Hydrogen peroxide is toxic at high levels, so cells get rid of it via the enzyme catalase. Though it is widely known that mercury inhibits catalase, it may do so by binding to sites other than sulfhydryl groups. It is interesting to note that when a person absorbs elemental mercury, which causes brain damage, catalase is the enzyme in the red blood cells that converts elemental mercury into an ionic form (mercuric salt).

Creatine Kinase

Mercury also inhibits the enzyme found in skeletal muscle called creatine kinase. Muscle cells contract by using an energy molecule called adenosine triphosphate (ATP), a molecule with three -- thus the “tri” prefix -- phosphates. Energy is released for an enzyme when the enzyme grabs ATP and breaks off one phosphate, resulting in adenosine diphosphate (ADP) -- “di” means two. A quick way of making ATP is to take a phosphate from a sugar molecule called phosphocreatine and add it to ADP. Creatine kinase is the enzyme that recharges ADP into ATP in this way. Mercury inhibits creatine kinase in several ways. Mercury blocks creatine kinase’s ability to bind ADP or the magnesium ion that the enzyme needs in order to function properly.

Digestive Enzymes

Mercury binds to sulfhydryl groups, which is found on the amino acid cysteine. Since cysteine is a common amino acid in many enzymes, mercury inhibits a whole host of enzymes. The "Journal of Applied Toxicology" reported the effects of inorganic mercury in the liver tissue of freshwater fish. Mercury inhibited many enzymes involved in digestion of food molecules, such as protein, carbohydrate and fat: amylase, lipase, lactase and maltase. Mercury also inhibited glucose-6-phosphatase, an enzyme involved in the production and export of glucose in cells.

A Heads-Up Look at Brain Health

Medical advances of today and the very near future — gene therapies, nanotechnology, targeted monoclonal antibodies, cloning, and more — will allow us to “repair” or “replace” damaged and diseased body parts and raise the average life expectancy to 100 years or more. The problem with this magnificent advancement is the studies which suggest that 40% of those reaching 85, and nearly 100% of those reaching 120, will be senile. Of what use is living to a ripe old age if we cannot enjoy it, or even be aware that we’re alive?

Brain Studies

Some 2000 years ago the ancient Greeks attributed all behavior to four temperaments: Hot, Dry, Moist, and Cold. The Romans attributed all symptoms and behaviors to four body fluids, which they called humors: Phlegm, Yellow Bile, Black Bile, and Blood. While Hippocrates, Galen, and hundreds of others slowly advanced the understanding of human anatomy and physiology, the brain sat unstudied for over 1500 years. It was not until the 18th and 19th centuries that brain anatomical science progressed to the point that four distinct lobes were identified, with specific behaviors and body functions ascribed to each.

Over the next 100 years, biochemical and pharmaceutical researchers discovered four separate brain chemicals, called neurotransmitters, that were used by the brain. Somewhat later, four distinct brain waves, or patterns of electrical activity, were discovered and correlated with specific lobes in the brain. Only fairly recently have researchers started to understand this most mysterious organ.

From the 1950s to present, psychiatrists and phychologists have described four broad classifications of human behavior: extroverted or introverted, intuitive or sensing, thinking or feeling, and perceiving or judging. If you suspect that these four primary behaviors can be assigned to a specific lobe, you’d be right!

Brain malfunctions, as manifested by psychiatric problems or unacceptable behavior, can be largely attributed to an imbalance of neurotransmitters within the brain. Unfortunately, discovering these levels within a living brain was not an easy task. (If you think a spinal tap is a risky procedure, just imagine a “brain tap” gone wrong!) What was needed was a simple, noninvasive test to measure the levels of neurotransmitters in a functioning human brain. Various scans of the brain can be employed, but they cannot show actual brain function. For example, an MRI of a patient’s brain right before death and right after death would be identical.

After 25 years of painstaking work, neurological researchers have finally uncovered a long-hidden piece of the puzzle — the relationship between the brain’s chemicals and the brain’s electricity. This discovery allowed clinicians to diagnose brain dysfunction with a simple, noninvasive assessment of the brain’s electrical activity. By measuring the four electrical components of brain activity, doctors can determine the levels of the four neurotransmitters and initiate treatment protocols to correct a deficiency of one or more of them.

Correlation Times Four

Four temperaments; four humors; four neurotransmitters; four lobes; four classes of human behavior; four brain waves; four electrical measurements of brain function. How do these relate? The following table shows the relationship between brain lobes, neurotransmitters, behaviors or personality types, and electrical measurements.

The table above shows the electrical measurements used to determine neurotransmitter levels. As a person ages, his brain goes through a slow decline, or “electropause,” in which the voltage, speed, rhythm, and synchrony change. By measuring these four electrical characteristics, a person’s “brain age” can be determined, which may be younger or older than typical for his chronological age. More importantly, a deficiency in one or more neurotransmitters can be detected and steps taken to restore normal levels.

A computerized diagnostic device called a Brain Electrical Activity Map (BEAM) measures these four values and creates a “picture” of the brain’s electrical activity. It records and tracks the progression of the positive wave created in the brain by an external stimulus, such as a sound (auditory evoked potential) or a flash of light (visual evoked potential).

Speed. A “normal” brain takes about 300 msec (milliseconds) plus a person’s age in years to “think.” This is the measurement of the time delay, or latency, between a stimulus given and the recognition of that stimulus in the brain. As the latency increases (speed decreases), a person moves from mild cognition deficits to severe dementia.

Voltage. A “normal” brain creates an electrical potential of about 10 µv (microvolts). The voltage generated in a person’s brain is related to his ability to concentrate, and low voltage can result in memory impairment, obesity, addictions, or schizophrenia.

Rhythm refers to the regularity of a person’s brain waves. Like cardiac rhythm, the more smooth the rhythm, the better. Brain-wave arrhythmias yield a spectrum of disorders from anxiety and recurring headaches to manic depression and seizures.

Synchrony is a comparison of the electrical activity in each of the hemispheres of the brain. It is common for a person to be dominant in one hemisphere or the other, but a severe imbalance in the electrical activity of the right vs. left hemisphere can lead to sleep disorders, IBS, somatization disorders, or phobias.

Acetylcholine

Review: A “normal” brain takes about 300 msec (milliseconds) plus a person’s age in years to “think.” This is the measurement of the time delay, or latency, between a stimulus given and the recognition of that stimulus in the brain. As the latency increases (speed decreases), a person moves from mild cognition deficits to severe dementia.

Acetylcholine-associated disease states

A diagnostic evaluation of a person’s brain speed can give objective evidence of disturbances in cognition, memory, attention, and behavior. After subtracting the patient’s age, the baseline latency measurement indicates the following: 300 msec is “normal”; 350 msec indicates mild to moderate disturbances in cognitive function (“muddled thinking”); 360 to 370 msec indicates ADD or variability of attention, errors of omission or commission, and delayed reaction time; 380 msec is typically found in Parkinson patients; 420 msec is the threshold for Alzheimer disease, with increasing latency as the dementia progresses. Early detection of deficiencies in the speed at which the brain operates can allow early intervention to slow or reverse the decline, possibly delaying or preventing the onset of Alzheimer and other dementias.

Beyond detecting a frank disease state associated with severe acetylcholine deficiency, physicians can analyze thebalance of the four neurotransmitters to determine a patient’s personality type.

The acetylcholine-dominant personality

Acetylcholine is produced in the parietal lobes, which are responsible for thinking functions such as language processing, intelligence, and attention. People with an excess of acetylcholine (about 17% of the world’s population) are adept at working with their senses and view the world in sensory terms. They are quick thinkers, highly creative, and open to new ideas. Flexibility, creativity, and impulsivity open them up to trying almost anything, as long as it offers the promise of excitement and something new; they are not afraid of failure. They love to travel and have a quest for lifelong learning. These people also tend to be extremely sociable, even charismatic. They love making new friends and put a lot of energy into all of their relationships, whether at work, at home, or in the community. They are eternally optimistic, romantic with their significant other, and attentive to the needs of their children. They are quite popular with a broad range of people. People with extremely high levels of acetylcholine, however, risk giving too much of themselves to others, even to the point of being masochistic. They may feel that the world is taking advantage of them, or they may become paranoid. Too much acetylcholine can drive a person into isolation.

The acetylcholine-deficient personality

Low levels of acetylcholine result when either the brain burns too much or produces too little. Shifts in personality occur at a much milder deficiency than the dementia- producing deficiencies mentioned earlier. These personality traits can, in fact, manifest when the acetylcholine level is only slightly lower than the levels of the other three neurotransmitters. And remember, we’re looking at the relative balance of neurotransmitters. A deficiency in one neurotransmitter is usually offset by an excess of another, which typically produces the personality traits associated with a dominance of that other neurotransmitter.

The eccentric. The absence of thought connections to other people and the world makes this person’s behavior seem odd. The eccentric usually steers away from human interaction and keeps himself isolated. Outwardly, he appears bland and inexpressive. When even mildly stressed, however, he can become a danger to himself and others.

The perfectionist. This person is usually hard working, detail oriented, devoted, and exacting. Self-discipline is a hallmark of this personality type, which can be either a plus or a minus, depending on the severity of the imbalance and which other neurotransmitter is dominant. This person can be an excellent worker, or he can be rigid and obsessive to the point that nothing is actually accomplished. The perfectionist’s life is usually lacking in enjoyment, relaxation, and warmth, which can make that person unapproachable.

Dopamine

Review: A “normal” brain creates an electrical potential of about 10 µv (microvolts). The voltage generated in a person’s brain is related to his ability to concentrate, and low voltage can result in memory impairment, obesity, addictions, or schizophrenia.

Dopamine-associated disease states

A person’s ability to concentrate can be directly correlated with his dopamine level. A diagnostic evaluation of the voltage in a person’s brain can give objective evidence of disturbances in concentration and memory. Low dopamine levels can be involved in difficulty performing routine tasks, a variety of sexual disorders such as loss of libido or anorgasmy, various addictions, from caffeine to opiates, and decreased physical activity due to fatigue. Obesity is a common result of the combination of sugar cravings and low physical activity associated with suboptimal dopamine levels in the brain.

Brain voltage can vary within the range of 0 µv (dead) to 20 µv (super concentration), with 10 µv being classified as “normal.” The voltage range correlates as follows: 0-2 µv is typically found in cocaine babies; 2-4 µv can indicate severe addictions, severe attention deficit disorder, or schizophrenia; 5-6 µv indicates a chronic brain disorder; 7 µv is found in those with moderate addictive behavior, such as caffeine and sugar cravings; 8-9 µv is typical for mild to moderate memory and thinking disturbances, including mild attention deficit; 10 µv is “normal”; and above 10 µv indicates an increased ability to concentrate, even to the rejection of external stimuli at the high end of the range.

Drugs that increase dopamine levels have been used as adjunctive therapy for schizophrenia and opiate addiction. Beyond detecting and treating frank disease states associated with a severe dopamine deficiency, physicians can analyze the balance of the four neurotransmitters to determine a patient’s personality type.

The dopamine-dominant personality

Dopamine is the source of the brain’s power and energy. People with an excess of dopamine (about 17% of the world’s population) thrive on energy. They are likely to be strong-willed individuals who know what they want and how to get it. They are highly rational, more comfortable with facts and figures than feelings and emotions. They can be self-critical, but do not accept criticism or negative feedback from others. These people function well under stress, focusing intently on the task at hand. They are tireless and typically need less sleep than average. Strategeic thinking, invention, and problem-solving are the hallmarks of these individuals. In their personal lives, they like activities related to knowledge and intellect. They can be competitive in sports, but prefer individualized sports over group sports. They tend to establish personal relationships easily, but may have trouble nurturing them. As highly rational people, they have trouble understanding that many people believe feelings are more important than reason. They have a tendency to want to exert control over their spouse and children, and a successful marriage depends on the loyalty and goodwill of the spouse.

People with extremely high levels of dopamine, however, can be overly intense, driven, and impulsive. They may turn to violence as a way of creating controlled environments of excitement and power. Teens may be driven to shoplifting, street racing, or date rape. Criminals — especially repeat sexual offenders — often have extreme dopamine levels and a heightened libido that frequently accompanies it.

The dopamine-deficient personality

Low levels of dopamine result when either the brain burns too much or produces too little. Shifts in personality occur at a much milder deficiency than the disease- producing deficiencies mentioned earlier. Personality shifts can, in fact, manifest when the dopamine level is only slightly lower than the levels of the other three neurotransmitters. And remember, we’re looking at the relative balance of neurotransmitters. A deficiency in one is usually offset by an excess of another, which typically produces the personality traits associated with a dominance of that other neurotransmitter.

Dopamine production determines the brain’s power, as measured by voltage. As the voltage becomes suboptimal, the person literally slows down, mentally and physically. Minor deficiencies can produce a range of mental and physical symptoms, such as mild memory loss, mild depression (“the blues”), panic disorder, PMS, insomnia, fatigue, mild hypertension, nicotine addiction, and obesity. Sexual side effects, such as loss of libido and difficulty achieving orgasm, are common among people with a dopamine deficiency.

The previous two neurotransmitters — acetylcholine and dopamine — can be thought of as the brain’s “on” switch, providing energy, power, and speed. The next two — gamma-aminobutyric acid (GABA) and serotonin — function as the brain’s “off” switch, providing calmness, rest, and sleep. A balance of the “on” and “off” neurotransmitters is necessary for proper brain function.

GABA

Review: Rhythm refers to the regularity of a person’s brain waves. Like cardiac rhythm, the more smooth the rhythm, the better. Brain-wave arrhythmias, or dysrhythmias, yield a spectrum of disorders from anxiety and recurring headaches to manic depression and seizures.

GABA-associated disease states

Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the brain. It has a calming, stabilizing effect. It controls the brain’s rhythm, which allows a person to function at a steady pace and prevent him from becoming too “hyper.” As the brain’s GABA level declines, brain waves begin to become less rhythmic. This can bring on a multitude of symptoms, both psychological and physical.

Mild brain-wave dysrhythmias can produce anxiety and its accompanying physical manifestations: restlessness, sweating, cold or clammy hands, butterflies in the stomach, and a lump in the throat. Other physical symptoms that can appear with a moderate GABA deficiency include carbohydrate cravings, an abnormal sense of smell, and unusual allergies. As GABA levels further decrease, anxiety can become more pronounced and produce attention-deficit disorders, PMS, flushing, trembling, hypertension, cystitis, and gastrointestinal disorders. At the most extreme deficiency, this can become full-blown panic attacks, manic depression, migraine headaches, hyperventilation, palpitations, tachycardia, blurred vision, tinnitus, twitching, and seizures. Advanced psychological symptoms can include severe delusions, feelings of dread, and a short temper that can progress into full-blown rage reactions and violence. Chronic marijuana and alcohol abuse can signal an acute GABA deficiency.

Beyond detecting and treating frank disease states associated with GABA deficiencies, physicians can analyze thebalance of the four neurotransmitters to determine a patient’s personality type.

The GABA-dominant personality

People with high GABA levels (about 50% of the world’s population) share the common attributes of stability, consistency, sociability, and concern for others. They are nature’s most dependable people. They can be counted on to show up at work every day and be there when others need them. At work, GABA- dominant people are the ones who set goals, organize projects, schedule activities, and keep others on task. Their punctuality, objectivity, practicality, and confidence make them excellent employees. Organization is paramount to them — at work, at home, and in their social life. It’s no wonder that these people gravitate to careers as administrators, accountants, air-traffic controllers, meeting planners, nurses, EMTs, and yes, medical transcriptionists. They’re the ones in the group who stay focused on the matter at hand. They are the consummate team player, both metaphorically and literally. In their personal life, such people derive pleasure from taking care of their family and friends. They can be a serene island in a sea of chaos. Although they like group activities, they cherish one- on- one relationships. Their friends are forever, and their marriage is a long- term commitment. Nurturing and making others happy is their ultimate goal. They tend to be religious and believe in traditions, especially where friends and family are involved, such as holiday gatherings.

As with the other neurotransmitters, it is possible to have too much of a good thing. People who produce too much GABA can be organizational to the point of setting rigid schedules and micromanaging others, whether as a boss, a coworker, a friend, or spouse. Excess GABA can dramatically increase a person’s nurturing tendencies. They can spend enormous amounts of time and energy looking for opportunities to give love and care to others, at the cost of their own needs not being met.

The GABA-deficient personality

Low levels of GABA result when either the brain burns too much or produces too little. Shifts in personality occur at a much milder deficiency than the disease- producing deficiencies mentioned earlier. Personality shifts can, in fact, manifest when the GABA level is only slightly lower than the levels of the other three neurotransmitters. And remember, we’re looking at the relative balance of neurotransmitters. A deficiency in one is usually offset by an excess of another, which typically produces the personality traits associated with a dominance of that other neurotransmitter.

Unlike a balanced brain that creates energy in a smooth, steady flow, a person with low GABA creates energy in bursts. This brain dysrhythmia can upset the body in a number of ways, but none is more pronounced than in the realm of emotional well- being. Specifically, he can lose the ability to effectively deal with life’s stresses. He may begin to feel nervous, anxious, and irritable. He may demonstrate poor emotional stability, lack impulse control, and resort to childish behavior. It can also manifest as poor verbal memory and difficulty concentrating. Physically, low GABA levels can bring on a variety of subacute conditions such as allergies, transient aches, instability while walking, diarrhea or constipation, and insomnia or hypersomnia. Usually, such physical annoyances occur one after another to the point that a person begins to wonder about his general state of health.

Serotonin

Review: Synchrony is a comparison of the electrical activity in each of the hemispheres of the brain. It is common for a person to be dominant in one hemisphere or the other, but a severe imbalance in the electrical activity of the right vs. left hemisphere can lead to sleep disorders, IBS, somatization disorders, or phobias.

Serotonin-associated disease states

Correlating with delta waves in the brain, serotonin affects your ability to rest, regenerate, and find serenity. Adequate serotonin allows the brain to recharge and rebalance itself each night, so that you can begin each morning with a fresh start. Serotonin is produced in the occipital lobes, which is also the center of sight.

As serotonin levels drop, the right and left hemispheres become desynchronized, producing feelings of being out of control. Moderately low levels can produce depression, mild hypertension, arthritis, poor temperature regulation, sexual disturbances such as premature ejaculation or delayed arousal response, bowel disturbances, mild PMS with emotional outbursts, learning disorders, obsessive- compulsive behavior, and insomnia, which tends to further lower serotonin levels. As levels drop further, hypertension can become uncontrolled, arthritis can intensify, PMS can become severe, and a wide range of perimenopausal symptoms can occur. With a severe shortage of serotonin, physical and psychological disturbances may become life threatening, with bingeing, masochism, severe depression and other serious mood disorders, addictions including alcoholism and drug abuse, somatization disorders, schizoaffective disorders, and schizophrenia with hallucinations. Physically, a severe serotonin deficiency can cause insomnia/ hypersomnia sleep cycles measured in days and increase hypertension to the point of producing a stroke.

Beyond detecting and treating frank disease states associated with serotonin deficiencies, physicians can analyze the balance of the four neurotransmitters to determine a patient’s personality type.

The serotonin-dominant personality

People with high serotonin levels (about 17% of the world’s population) know how to live in the moment. Realistic and impulsive, they are highly responsive to sensory input. They’re active participants in life who thrive on change. They take their vacations at a different spot each year. They try new foods, new hobbies, and new friends, and they have a natural disdain for order, structure, and authority. They’re optimistic, cheerful, easygoing, and the life of the party. A serotonin-dominant person gravitates to trades or professions that offer a variety of tasks, an ever-changing environment, and interactions with different people. Their keen hand-eye coordination makes them well suited to using various tools to accomplish their tasks. Construction workers, truck drivers, military personnel, hairstylists, pilots, surgeons, chiropractors, movie stars, fashion models, photographers, and professional athletes likely owe their skills to ample serotonin levels. Preferred sports can include mountain climbing, hunting, skydiving, hang gliding, scuba diving — just about anything that offers a personal challenge along with a certain level of excitement. They play hard and have the time of their life when doing activities that others would consider too dangerous. In relationships, they can be romantic and passionate, but they also love their independence and often refuse to be tied down. Due to their impulsivity and desire for change, they tend to move away from people before deep relationships develop. In fact, their friendships are typically many and varied — wide instead of deep. They have a fondness for children, but make better aunts and uncles than parents.

As with the other neurotransmitters, it is possible to have too much. An excess of serotonin can make a person extremely nervous. He can become hesitant, distracted, hypersensitive to criticism, and morbidly afraid of being disliked. Excessive serotonin can make a person believe he is inadequate and inferior. Sadness and anger are constant companions, and although he may have a desperate desire for interpersonal interaction, he is too fearful to even make an attempt.

The serotonin-deficient personality

Serotonin deficiency can occur from experiencing too much excitement (thereby metabolizing large amounts of serotonin) and/or not getting sufficient sleep (causing the brain to generate less serotonin). Shifts in personality occur at a much milder deficiency than the disease- producing deficiencies mentioned earlier. Personality shifts can, in fact, manifest when the serotonin level is only slightly lower than the levels of the other three neurotransmitters. And remember, we’re looking at the relative balance of neurotransmitters. A deficiency in one is usually offset by an excess of another, which typically produces the personality traits associated with a dominance of that other neurotransmitter.

A common sign of serotonin deficiency is depression and fatigue. The chronic lack of sufficient sleep means that the brain is unable to rest, regenerate, and resynchronize. This can manifest in the personality as a flat affect (a classic sign of depression) and a lack of pleasure, artistic appreciation, and common sense. The person may become codependent, obsessive- compulsive, or exhibit loner tendencies. He can be impulsive or perfectionistic, painfully shy or masochistic. Someone with multiple phobias is typically serotonin deficient. The frequent use of ecstasy, PCP, and LSD also signals a serotonin deficiency.

Lettin’ the good guys in,
Keepin’ the bad guys out

We have been made with a wonderful mechanism to prevent harmful substances from entering the brain. Not everything that circulates in the blood stream is allowed entry into the brain. There is a barrier between the blood and the brain, logically called the blood-brain barrier, that allows only glucose and certain nutrients selective access to the brain. This membrane protects the brain from toxins and other substances that would cause it damage. It also “holds in” certain substances manufactured by the brain, notably neurotransmitters, that would be lost through diffusion throughout the rest of the body if allowed to pass into the blood stream. Therefore, the same membrane that prevents toxins from passing through also prevents neurotransmitters from passing through. This characteristic of the blood-brain barier is the reason why a Parkinson disease patient, for example, cannot receive an injection of dopamine to restore the dopamine level in his brain and reverse the disease. So the dilemma is how to raise the level of specific neurotransmitters in the brain, when simple supplementation with those neurotransmitters is ineffective.

The answer lies in finding a way to “coax” the brain to produce more endogenous neurotransmitters. It turns out that the answer is fairly simple — give the brain more raw material, and it will make more neurotransmitters. Fortunately, the mechanism by which the brain makes each neurotransmitter is well known. Like most substances in the body, they are made through a series of chemical reactions. Notice that I said the blood-brain barrier allows only glucose and certain nutrients selective access to the brain. It is those “certain nutrients” that the brain uses to make neurotransmitters. If there is a deficiency in any of the nutrients needed to make a specific neurotransmitter, there will be a corresponding deficiency of that neurotransmitter. Supplementing the deficient nutrient(s) will allow the brain to resume full production of the neurotransmitter.

Building a better brain

So what are the “certain nutrients” that the brain must have? Without going into the chemistry of neurotransmitter manufacture, suffice it to say that the brain’s supply of amino acids is the most common limiting step in their production. Amino acids, the basic building blocks of protein, are also the basic raw material the brain uses to function. As such, they easily cross the blood-brain barrier. All amino acids can cross the blood-brain barrrier, in fact, but not all are used to make neurotransmitters. The problem is that all the amino acids circulating in the blood stream at any given time compete for passage through the “amino acid channels” in the blood-brain barrier, and passage of a specific amino acid is granted in proportion to its concentration in the blood. If you eat a steak or other complete protein source, all 20 amino acids are simultaneously competing for entry into the brain. Supplementing with, say, 1 gram of a certain amino acid won’t do much if you chase it with a glass of milk (15 grams of protein in 12 oz.) or take it with a meal. To be effective, amino acid supplements should be taken on an empty stomach with plain water or fruit juice (the fructose in juice helps escort the amino acid to the brain).

In the paragraphs that follow, I will tell you which amino acids are used to boost which neurotransmitter, and the primary food sources for that amino acid. Food sources are complex, however, and foods that boost the production of one neurotransmitter can also contain substances that boost the production of another. Eggs, for example, provide a tremenous boost for acetylcholine, but they also have a component that supports GABA. This is one reason why a change of diet takes longer to produce an effect than supplementation with pure amino acids. You should know that prescription drugs are also available to boost the production of a specific neurotransmitter or slow its destruction, but that is beyond the scope of this article. They are listed in detail in the reference given at the end of the article. (Note: numbers shown after the supplements listed below refer to the relative efficacy in boosting the neurotransmitter, on a scale of [1]=best to [4]=least effective.)

Boosting acetylcholine

• Pure amino acid precursors: serine, carnitine.
• Amino acid-boosting supplements: DMAE (dimethylaminoethanol) [1], phosphatidylcholine [1], phosphatidylserine [2], acetyl-L-carnitine [2], GPC (glycerol phosphocholine) [3].
• Supporting supplements: huperzine A [1], nicotine [1], lipoic acid (alpha-lipoic acid) [3], fish oils [3], manganese [4], conjugated linoleic acid [4].
• Hormonal supplements: DHEA (dehydroepiandrosterone) [2].
• Illegal supplements: LSD, PCP, psychotropic mushrooms.
• Dietary support: choline-rich foods, including avocado, cucumber, zucchini, lettuce, most fruit, bacon, bologna, hot dogs, chicken, turkey, pork, liver, fish, beef, milk, ice cream, sour cream, yogurt, cheese, eggs, and various nuts.
• Lifestyle support: aerobic exercise.

Boosting dopamine

• Pure amino acid precursors: phenylalanine, tyrosine.
• Amino acid-boosting supplements: N-acetyl tyrosine [2], L-tyrosine [3], phenylalanine [3]. (Note: most ingested phenylalanine is hydroxylated to tyrosine in the body. Tyrosine supplements, therefore, need one less chemical conversion step to be used by the body.)
• Supporting supplements: caffeine [1], guarana [1], yohimbe [1], ephedra[2], nicotine [2], Rhodiola rosea[3], thiamine [4], chromium [4], folic acid [4].
• Hormonal supplements: DHEA [2].
• Illegal supplements: cocaine, ecstasy, mescaline.
• Dietary support: phenylalanine- and tyrosine-rich foods, including wild game, duck, turkey, pork, chicken, luncheon meats, cottage cheese, ricotta, milk, yogurt, walnuts, soybeans, wheat germ, granola, rolled oats, dark chocolate, and eggs.
• Lifestyle support: sexual activity (for women), weight-bearing exercise, aerobic exercise.

Boosting GABA

• Pure amino acid precursor: glutamine.
• Amino acid-boosting supplements: L-glutamine [1].
• Supporting supplements: inositol [1], alcohol [1], B vitamins [2], glycine [3], kava [3], BCAA (branched-chain amino acids) [4], taurine [4].
• Hormonal supplements: progesterone [2].
• Illegal supplements: opioids, ketamine, marijuana, quaaludes.
• Dietary support: glutamine-rich foods (especially complex carbohydrates), including almonds, walnuts, and other tree nuts, whole-grain wheat and oats, rice bran, brown rice, lentils, potatoes, broccoli, spinach, bananas, citrus fruit, halibut, and beef liver.
• Lifestyle support: sexual activity (for men and women), sleep, aerobic exercise.

Boosting serotonin

• Pure amino acid precursor: tryptophan.
• Amino acid-boosting supplements: L-tryptophan [2], 5-HTP (5-hydroxytryptophan) [3].
• Supporting supplements: St. John’s wort [2], vitamin B6 [4], fish oils [4].
• Hormonal supplements: melatonin [1], progesterone [2].
• Illegal supplements: LSD, PCP, GHB, ecstasy.
• Dietary support: tryptophan-rich foods, including wild game, pork, luncheon meats, duck, turkey, chicken, wheat germ, cottage cheese, and eggs.
• Lifestyle support: aerobic exercise, psychotherapy, sleep.

To learn more

This series of articles is a synopsis of the groundbreaking research of Eric R. Braverman, MD, as presented at the American Academy of Anti-Aging Medicine (A4M) Annual Conference, June 2003. Dr. Braverman was a member of the pioneering research team at Havard University that developed the BEAM (Brain Electrical Activity Map), a noninvasive device to measure neurotransmitter levels in functioning brains through electrical activity. For more information, his book, The Edge Effect, is highly recommended reading.

Low Zinc / B6

Takeaway: If you're low in zinc, you will not have enough GABA to combat excess levels of norepinephrine. And if you are low in B6, you are likely to have problems with the same neurotransmitter.

The Importance of Zinc

The human body absorbs approximately 400kg zinc over the average 70-year lifespan and at any one time there should be 2-4 gm zinc in the body. It is the second most abundant mineral ion ( Magnesium is the first) in the body and is the only metal that appears in all enzyme classes The body absorbs 20-40% of zinc in food, zinc from animal foods being more readily absorbed (twice as much ) than zinc from plant foods. Zinc is also more readily absorbed with a protein meal and although the body cannot store zinc and it is needed every day in small amounts (50mg or less), it may be held in metallothionine reserves and transferred in metal transporter proteins. Metallothionines in the intestinal cells are capable of adjusting the absorption of zinc by 15-40%. Thus control of cellular zinc homeostasis is maintained by zinc proteins and zinc binding metallothioneines. Zinc is needed for over 300 enzymes in the body and makes up part of 3000 different proteins in the body. Muscles (60%) and bones (30%) contain 90% of the body’s zinc. High concentrations of zinc are found in the prostate gland and semen and the choroid of the eye.

If bone is reabsorbed or muscle is broken down then some zinc can be reutilised and in cases of zinc depletion changes in immune status alter before any decrease in levels of plasma zinc. There is a small exchangeable pool of zinc (100-200mg ) that depends on recently absorbed zinc and the intestinal excretion of zinc. As with Magnesium, the efficiency of absorption of zinc is inversely related to the amount of zinc present in the body. The greater the level of body zinc, the less absorption occurs. Zinc, Magnesium Calcium and Iron all compete for transporters in the intestine for uptake above a threshold of approximately 800mg so consuming these minerals together below this level should not interfere with uptake Zinc is found in all cells in the body and the daily requirement is dependent on age and activity.

Zinc deficiency is due to

• Soil deficiency.

• Some drugs deplete zinc.

• Vegetarian and vegan diets may be deficient.

• High cereal based diets, containing high phytate foods which can bind with zinc and impair absorption.

• Cooking with water can result in leaching of up to 50% of zinc levels of the food.

• Refined processing of wheat and baked goods can result in up to 75% zinc loss

Tetracycline and quinolone antibiotics react with zinc in the intestines inhibiting the absorption of both the antibiotic and zinc. The antibiotic should be taken 2 hours or more before or at least 4-6 hours after the zinc supplement to avoid this. 

In short over 300 enzymes are zinc dependent, including enzymes involved in the synthesis of certain proteins such as collagen and wound healing. Also needed for thymic hormone activation and maintaining a normal immune system, testosterone and oestrogen, fertility and reproduction including cell division. It is involved in gene regulation, maintaining acid/base balance in the body and normal carbohydrate, fat and protein metabolism. It is needed for normal bones, skin, hair and nails and normal brain function including maintenance of normal vision. It can also act as an antioxidant, protecting DNA, lipids and proteins in the body.

Zinc Contributes to

Normal DNA synthesis. Although the exact role of zinc in DNA synthesis is not fully understood but it does play a structural role in zinc fingers, which are finger shaped proteins. Due to their shape, these proteins can bind to DNA and RNA allowing them to function in Gene expression. These proteins are the most common transcription factors in living organisms, transcription factors are proteins that bind to DNA and control the transfer of genetic information to RNA Put simply Zinc is needed for reading genetic instructions and lack of zinc may mean that instructions get misread or not read at all.

Normal acid/base metabolism. Acid/Base balance is the balance between acid and alkaline to keep body fluids as close to a neutral pH (pH7) as possible. Carbon dioxide and water are rapidly converted to bicarbonate and water (and back again) to maintain acid base balance in the blood and other tissues. The enzyme responsible for this is the zinc dependent enzyme Carbonic Anhydrase. Studies have shown that dietary deficiency of zinc reduces red blood cell carbonic anhydrase activity

Normal carbohydrate metabolism. Deficiency of zinc results in a drop of metabolic rate. Zinc dependent messenger RNA is needed to synthesise the enzymes required for carbohydrate metabolism so zinc deficiency may result in lack of these enzymes. Zinc may also interact with insulin by controlling the uptake of glucose by adipocytes (fat cells). Zinc deficiency results in impaired carbohydrate metabolism.

Normal cognitive function Zinc is highly concentrated in the cerebral cortex, pineal gland and hippocampus and zinc deficiency is associated with impaired memory formation and mood disorders. In the hippocampus zinc can reach concentrations of 8% of the total brain zinc. Zinc ions are also NDMA (N-methyl-D –aspartate) antagonists (NDMAs control memory function and excessive NDMA activation results in cell death due to excess calcium influx into neuronal cells ) so zinc becomes important for normal neuronal function and memory and delaying brain cell death . Normal fertility and reproduction. Steroid hormones such as testosterone and oestrogen are derived from cholesterol and zinc plays an important role in cholesterol metabolism. Low dietary zinc is associated with low concentrations of several hormones including testosterone.

Testosterone. Circulating testosterone and free testosterone appears to increase with oral zinc intake. In one study supplementing with 250 mg zinc sulphate for 6 weeks increased testosterone by 85% in people on hemodialysis.

Free Testosterone is converted to DHT (dehydrotestosterone) by the enzyme 5alpha-reductase ) primarily in the prostate gland, testes , adrenal glands and hair follicles. DHT is increased in infertile men and as it has an affinity for the hair follicles can result in male pattern baldness. Zinc has been shown to inhibit ( up to 98%)the enzyme 5 alpha reductase.

Semen: Semen is very rich in zinc. Sperm count, motility and physical characteristics of sperm increase and improve with some groups of infertile men.

Zinc deficiency has also been associated with increased expression of oestrogen receptors. The enzyme aromatase converts testosterone to oestrogen and zinc decreases aromatase activity so preventing excessive conversion of testosterone to oestrogen. Zinc deficiency can cause testicular cell death, increase protein oxidation in the testes, dysregulating other enzymes and proteins resulting in degeneration of testicular structures and impaired testosterone secretion.

Why should I Take A Zinc Supplement?

Normal macronutrient metabolism. Macronutrients are carbohydrates, fats and proteins. Zinc is needed for the enzymes that metabolise carbohydrates, fats and proteins

Normal metabolism of fatty acids- zinc is needed for the conversion of linoleic acid to Gamma Linolenic acid (GLA) and for the synthesis of prostaglandins series 1 ( Anti inflammatory prostaglandins) Zinc also plays an essential role in maintaining a balance between to different forms of prostaglandins.

Maintenance of normal serum testosterone concentrations, so involved in fertility and reproduction. Zinc plays a role in cell signalling, influencing hormone release and nerve function.

Normal metabolism of vitamin A. Zinc is necessary to maintain normal concentrations of vitamin A in the plasma, being essential for normal mobilization of Vitamin A from the liver. Zinc deficiency decreases the synthesis of Retinol Binding protein (RBP) in the liver leading to lower levels of RBP in the plasma.It influences the absorption, transport and utilisation of Vitamin A. . Zinc is also required for the enzyme Alcohol dehydrogenase , responsible for converting retinol to retinal, essential for eye function.

Normal protein synthesis. One of the important zinc dependent proteins is Gustin which is involved in taste and smell. Poor or absent gustin levels results in impaired taste and smell. Other important zinc containing enzymes are carboxopeptidase which helps break down protein. Zinc deficiency also impairs the synthesis of the protein Opsin, the precursor of Rhodopsin, which if decreased, results in abnormal dark adaptation of the eye. Zinc is also required for the enzyme alcohol dehydrogenase , responsible for converting retinol to retinal, essential for eye function. Haemoglobin is a protein and zinc s important in haemoglobin synthesis.

Maintenance of normal bones. Zinc regulates the secretion of calcitonin from the thyroid gland and therefore influences bone turnover. Zinc appears to regulate the bone matrix calcification in osteoblasts. Zinc deficiency decreases the activity of matrix proteins, type 1 collagen and alkaline phosphatase decreasing Calcium and Phosphorus accumulation. Therefore zinc deficiency may become a risk factor for poor extra cellular matrix calcification.

Maintenance of normal hair and nails Zinc is needed for building keratin and formation of collagen and for facilitating cell division that makes hair growth possible.

Maintainance of normal skin. Collagen in skin is produced by zinc dependent enzymes , the collagenases. Type 1 collagen is produced in the skin and is a structural long lived protein produced by fibroblasts. Collagen constitutes 70% skin mass and give the skin its structure and resistance to traction and strains. Total collagen decreases 1% a year resulting in decreased elasticity and aging skin. Zinc is essential not only for the enzymes producing collagen but also the cross linking that give collagen its stability. Human studies have shown that decreased zinc resulted in decreased total collagen.

Maintenance of normal vision Zinc supplementation alone significantly reduced the risks of developing AMD in subjects at higher risk. Zinc deficiency also impairs the synthesis of the protein Opsin, the precursor of Rhodopsin, which if decreased, results in abnormal dark adaptation of the eye. Zinc is also required for the enzyme alcohol dehydrogenase , responsible for converting retinol to retinal, essential for eye function.

Contributes to normal function of the immune system. Plays a central role in the immune system affecting cellular and humoral immunity. It is essential for thymic dependent T cells . Zinc deficiency results in decreased levels of all types of white blood cells. It is also required for the production of Thymulin (thymic hormone) Zinc ions also exhibit direct anti microbial activity.

Contributes to protecting the cells from oxidative damage, protecting the DNA, lipids and proteins . Loss of zinc from biological membranes increases their susceptibility to oxidative damage. Zinc is also necessary for the antioxidant enzyme Super Oxide Dismutase (SOD)and low levels of zinc supplementation resulted in increased levels of glutathione peroxidase , SOD and decreased lipid peroxidation.

The process of cell division. Zinc contributes to normal DNA synthesis and cell division. Zinc appears to be essential for Insulin like growth factor (IGF) which induces cell proliferation. Reduced zinc availability appears to affect membrane signalling and secondary messengers that coordinate cell proliferation. Ref : The Role of Zinc in Growth and Cell Proliferation by Ruth MacDonald published In The American Society for Nutritional Sciences Reference

What Are The Symptoms Of A Mild Zinc Deficiency?

• Loss of appetite.

• Poor growth.

• Weight loss.

• Diminished taste or smell.

• Poor wound healing.

• Skin problems, acne, psoriasis atopic dermatitis.

• Poor vision, night blindness.

• White spots on finger nails.

• Depression, apathy.

What Are The Symptoms Of A Severe Zinc Deficiency?

• Delayed sexual and bone maturation

• Skin lesions

• Diarrhoea

• Loss of appetite

• Hair loss

• Increased susceptibility to infections

• Behavioural changes

The passage of zinc into the body

Studies involving direct comparison of bioavailability of different forms of zinc in humans are few. The important fact is that the form of zinc needs to become dissociated into zinc ions which then bind to ligands ( proteins ) that transport the zinc into the cells of the small intestine. There are specific transport proteins that carry zinc across the cell membrane into the portal circulation where it is transported directly to the liver before being released into the circulation for delivery to all tissues. Approximately 70% of zinc is bound to serum albumin ( a plasma protein ) and factors altering serum albumin in turn affect serum zinc levels. Serum zinc has a rapid turnover to meet tissue demands.

Zinc is lost through the skin and kidneys (combined loss of 0.5-0.8mg/day) , more zinc being lost when the body sweats more, as in hot climates and during strenuous exercise. Approximately half of all zinc eliminated from the body is lost through the shedding of epithelial cells in the gastro intestinal tract (0.5- 3mg/day) and although a considerable amount is secreted through both biliary and intestinal secretions, most of the secretions are reabsorbed regulating the zinc balance. Starvation and muscle breakdown also increase zinc loss through the urine.

As already mentioned, protein enhances the absorption of zinc and a phytate rich diet (from cereals, grains, corn and rice) inhibit the absorption of zinc.

There is a very fine balance between zinc and copper. Zinc reduces the amount of copper your body absorbs because copper competes with zinc to bind with metallothionein, the binding protein that brings zinc into the intestinal cells. The ratio of zinc : copper is arguably more important than the concentration of either copper or zinc, a common problem being excessive copper in water from copper pipes or copper cookware.

Zinc also competes with iron to bind with blood transferring, illustrating the importance of a balance of these minerals. The ECRDA for zinc is 10 mg less is required for babies, children and teenagers and more for pregnant and breastfeeding ladies.

Recommended Daily Allowance For Zinc Supplements

Bioavailability Of Different Forms Of Zinc Supplements

There are many forms of zinc compounds. 

• Zinc Picolinate 20%

• Zinc Ascorbate 15%

• Zinc Chloride 48%

• Zinc Sulphate 22%

• Zinc Carbonate 52%

• Zinc Citrate 31%

• Zinc Bisglycinate 25%

There is not much substantial evidence of greater effectivity of one form of zinc over another as absorption of zinc in the body is subject to so many variables.

However, a small research study (15 healthy young adults in a randomised, double blind three way cross over study, receiving 10mg of elemental zinc as a supplement without food just published (20 November 2013) found that the bioavailability of zinc citrate was 61.3% , of zinc gluconate was 60.9% and of zinc oxide was 49.9 % Previous zinc intake may affect zinc bioavailability studies. Variables include;

• Existing zinc status of the individual. The lower the zinc status of the individual, the greater the absorption of zinc.

• People that sweat a lot are subject to more zinc loss, for example athletes, those in hot climate, menopausal ladies experiencing night sweats.

• Dosage of zinc- as zinc intake in dosages is increased , percentage absorption decreases probably due to the saturation of the transport mechanisms.

• Zinc absorption appears to be decreased in the elderly.

• Zinc absorption is increased with dietary protein intake.

• The type of protein in a meal affects zinc bioavailability. Animal protein enhances absorption.

• Phytates in cereals and soy inhibit absorption of zinc by binding with it ( except zinc bisglycinate found in Metabolics zinc formula).

• Caesin in milk and calcium inhibit absorption by binding with zinc ions.

• Iron inhibits absorption of zinc.

• Copper ( in high amounts ) inhibits Zinc absorption. In studies using 15mg zinc combined with 2mg copper no inhibition of absorption was found.

• Cadmium- toxic levels of cadmium can inhibit zinc absorption

Conclusion

Types of zinc supplements may remain a personal preference, although generally zinc should not be taken on an empty stomach (as it can result in nausea) should be taken with an animal protein meal , away from cereals and taken in conservative doses to increase absorption. Long term zinc intake is recommended with copper (see zinc formula) as this is zinc bisglycinate, the only form not affected by phytates and balanced with a small amount of copper.

Enter coupon code: SSSCZinc to save 10%

Resistance Training’s Effect on Endurance Performance

Research shows that the appropriate integration of resistance training into the endurance athlete’s training can result in significantly better performance when compared to classic endurance training plans that focus only on aerobic endurance.

The following is an exclusive excerpt from the book Developing Speed, part of the NSCA’s Science of Strength and Conditioning Series with Human Kinetics.

Endurance athletes who are stronger can generally perform at a much higher level.

This suggests that training modalities that stimulate increases in muscular strength without compromising endurance capacity may be beneficial for the endurance athlete. Support for this contention can be found in the scientific literature; research shows that the appropriate integration of resistance training into the endurance athlete’s training plan can result in significantly better performance when compared to classic endurance training plans that focus only on aerobic endurance training.

When looking closely at endurance performance, several key factors—including the athlete’s maximal aerobic power (V˙ O2max), lactate threshold, and movement efficiency—contribute to performance (see figure 7.1). The training modality selected influences these factors by inducing changes to the athlete’s aerobic power and capacity, anaerobic capabilities, and neuromuscular function.

Aerobic training exerts a strong influence on both aerobic power and capacity, but it does not exert a great impact on the athlete’s anaerobic or neuromuscular abilities.

Conversely, resistance training exerts a strong influence on the athlete’s neuromuscular function and a moderate influence on anaerobic power and capacity, while offering only a minimal influence on aerobic power and capacity. By influencing the athlete’s anaerobic abilities as well as neuromuscular function, resistance training can elevate the athlete’s lactate threshold, movement efficiency, and ability to engage in high-intensity activities.

The ability of resistance training to improve endurance performance is likely related to several key factors, including the specific physiological and mechanical adaptations that are stimulated by the resistance training regimen. The integration of resistance training into the overall training plan appears to be central to creating these specific performance-enhancing adaptations.

Traditionally, endurance athletes and coaches have believed that resistance training either does not affect or negatively affects endurance performance. However, this view may be partially explained by a design flaw in many of the training programs that include both resistance and endurance training. The flaw is that resistance training is simply added to the endurance training plan. Athletes who undertake this approach often experience excessively high levels of fatigue that can negatively affect overall performance.

If athletes reduce their endurance training load to account for the addition of resistance training, then resistance training has a positive effect on the athletes’ endurance performance. The athlete who performs both resistance and endurance training in an integrated and appropriately planned fashion will perform at a higher level than the athlete who performs only classic endurance training.

Understanding Methylation

Methylation is a key biochemical process that is essential for the proper function of almost all of your body’s systems. It occurs billions of times every second; it helps repair your DNA on a daily basis; it controls homocysteine (an unhealthy compound that can damage blood vessels); it helps recycle molecules needed for detoxification; and it helps maintain mood and keep inflammation in check.

To keep methylation running smoothly you need optimal levels of B vitamins. Without enough B vitamins methylation breaks down, and the results can be catastrophic. In these cases we see more birth defects like spina bifida, more cases of Down’s syndrome, and more miscarriage.

A breakdown in methylation also puts you at higher risk for conditions like osteoporosis, diabetes, cervical dysplasia and cancer, colon cancer, lung cancer, depression, pediatric cognitive dysfunction ( mood and other behavioral disorders), dementia, stroke and may put you at a higher risk of heart disease.

To avoid all of these problems, the key is to maximize methylation. That means avoiding the things that cause your methylation to break down, testing to find out how well your methylation is working, and including the things that support proper methylation. Let’s look at how to do that.

8 Factors that Affect Your Methylation Process

1. Genetics – Like an estimated 20 percent of us, you could be genetically predisposed to high homocysteine
2. Poor diet – The word “folate” comes from “foliage.” You need to eat plenty of leafy greens, beans, fruit, and whole grains to get adequate levels of vitamins B6 and B12, betaine, and folate. Egg yolks, meat, liver, and oily fish are the main dietary sources of vitamin B12 — so long-term vegan diets can be a problem. Plus, certain compounds can raise levels of homocysteine and deplete the B vitamins. These include excess animal protein, sugar, saturated fat, coffee, and alcohol. Irradiation of food depletes nutrients, so foods treated this way may be lower in B vitamins, too
3. Smoking – The carbon monoxide from cigarette smoke inactivates vitamin B6
4. Malabsorption – Conditions like digestive diseases, food allergies, and even aging can reduce absorption of nutrients
5. Decreased stomach acid – Aging and other conditions can reduce stomach acid — and therefore absorption of vitamin B12
6. Medications – Drugs like acid blockers, methotrexate (for cancer and arthritis and other autoimmune diseases), oral contraceptives, HCTZ (for high blood pressure), and Dilantin (for seizures) can all affect levels of B vitamins
7. Other conditions – These include hypothyroidism, kidney failure or having only one kidney, cancer, and pregnancy
8. Toxic exposures – Some toxins can interfere with vitamin production

Watch out for these factors and you will go a long way toward protecting your methylation.

Measuring Your Own Methylation Process

To find out if your methylation process is optimal, ask your doctor for the following tests:

• Complete blood count – Large red blood cells or anemia can be a sign of poor methylation. Red blood cells with a mean corpuscular volume (MCV) greater than 95 can signal a methylation problem
• Homocysteine – This is one of the most important tests you can ask for. The normal level is less than 13, but the ideal level is likely between 6 and 8
• Serum or urinary methylmalonic acid – This is a more specific test for vitamin B12 insufficiency. Your levels may be elevated even if you have a normal serum vitamin B12 or homocysteine level
• Specific urinary amino acids – These can be used to look for unusual metabolism disorders involving vitamins B6 or B12 or folate, which may not show up just by checking methylmalonic acid or homocysteine

12 Tips to Optimize Your Methylation Process

Just as there are many causes of poor methylation, there are lots of things that support its proper functioning. Here’s how to maximize methylation — and prevent conditions like heart disease, cancer, dementia, depression, and more.

1. Eat more dark, leafy greens – You want to eat l cup a day of vegetables like bok choy, escarole, Swiss chard, kale, watercress, spinach, or dandelion, mustard, collard, or beet greens. These are among the most abundant sources of the nutrients needed for optimal methylation
2. Get more Bs in your diet – Good food sources include sunflower seeds and wheat germ (vitamin B6); fish and eggs (vitamin B6 and B12); cheese (B12); beans and walnuts (vitamin B6 and folate); leafy dark green vegetables; asparagus, almonds, and whole grains (folate); and liver (all three)
3. Minimize poor quality animal protein, sugar, and saturated fat – Animal protein directly increases homocysteine. Sugar and saturated fat deplete your body’s vitamin stores
4. Avoid processed foods and canned foods – These are depleted in vitamins
5. Avoid caffeine – Excess amounts can deplete your B vitamin levels
6. Limit alcohol to 3 drinks a week – More than this can deplete your B vitamin levels
7. Don’t smoke – As noted above, smoking inactivates vitamin B6
8. Avoid medications that interfere with methylation – See notes on this above
9. Keep the bacteria in your gut healthy – Take probiotic supplements and use other measures to make sure the bacteria in your gut are healthy so you can properly absorb the vitamins you do get
10. Improve stomach acid – Use herbal digestives (bitters) or taking supplemental HCl
11. Take supplements that prevent damage from homocysteine –Antioxidants protect you from homocysteine damage. Also make sure you support methylation with supplements like magnesium and zinc
12. Supplement to help support proper homocysteine metabolism – Talk to your doctor to determine the best doses and forms for you.  Here are a few suggestions:
    Folate (folic acid): Amounts can vary based on individual needs from 200 mcg to 1 mg. Some people may also need to take preformed folate (folinic acid or 5 formylTHF) to bypass some of the steps in activating folic acid
    Vitamin B6: Take 2 to 5 mg a day. Some people may need up to 250 mg or even special “active” B6 (pyridoxyl-5-phosphate) to achieve the greatest effect. Doses higher than 500 mg may cause nerve injury
    Vitamin B12: Doses of 500 mcg may be needed to protect against heart disease. Oral vitamin B12 isn’t well absorbed; you may need up to 1 or 2 mg daily. Ask your doctor about B12 shots
    Betaine: This amino acid derivative is needed in doses from 500 to 3,000 mg a day, depending on the person

Understanding Cholesterol

Cholesterol is one of the least understood molecules and truly gets a "bad rap." Although people understand that cholesterol is only present in animal-based foods, what many do not know is that we produce cholesterol just like any other animal, and it is a very necessary molecule used to form all of the cell membranes in the body. Cholesterol is also the building-block molecule from which all of the steroid hormones are made. If there is more cholesterol in the diet than is needed, then the body synthesizes less. If the diet does not provide enough cholesterol then the body makes more.

Since cholesterol is used by the body to manufacture hormones such as cortisol, we can look at what cortisol is and make some logical connections. Cortisol is widely regarded as a "stress hormone" since the body needs and produces more of it in response to stress. This stress response takes many forms; one of them is lowering inflammation--useful if your version of stress involves hand-to-hand combat with large carnivores or fighting for your life. The lowering of inflammation is why the pharmaceutical versions of cortisol (Hydrocortizone and other glucocorticoids) are used to reduce inflammation in cases of massive trauma or major surgery. Other effects of cortisol are the elevation of blood pressure, release of glucose from the liver, inhibition of the immune system, retaining of water/reducing kidney function (probably useful if the combat with the large carnivores leads to bleeding form flesh wounds, as retaining water would help to maintain blood volume when bleeding profusely) and other effects. Taken together, when stress levels remain high, lots of cortisol is produced. It would then make sense that making a lot of cortisol requires a lot of what is made from, which is cholesterol. Therefor, during periods of high stress (a lifetime for many people), the levels of cholesterol can become very elevated. When the stress is long-term, the stress will end up raising the inflammation level through other mechanisms; effectively, stress reduces inflammation in the short-term only. Cholesterol has many other uses in the body, including the formation of myelin--the insulating/speeding sheath that wraps around the nerves, like rubber coating surrounding a copper wire, that increases their conduction velocity (and is damaged in multiple sclerosis).

Dietary modifications to reduce cholesterol has been met with mixed results. Some people can follow a strict no-cholesterol diet and achieve a lowering of their plasma cholesterol levels, while other are not able to accomplish this. This failure of dietary regimen to achieve the desired goal may be because of the body's production of cholesterol to meet the necessary levels for the amount of stress the individual is experiencing. The failure may also be because of reduced utilization of cholesterol. The gut bacteria play a role here also with Lactobacillus bacteria actively consuming cholesterol. Lactobacillus not only consumes cholesterol, but it makes bile acids that aid in the digestion of fats out of the cholesterol that it consumes. It therefore makes sense that if a person has altered gut bacteria demographies and Lactobacillus are in the minority, that person will not use up as much cholesterol and the cholesterol levels may accumulate. Elevated levels of stress reduce the levels of Lactobacillus, providing the pathway for stress to reduce the beneficial effects of a healthy diet. The same imbalance may also predispose the person to inflammation, which is the real cause of heart disease.

The use of probiotics in dairy products to control cholesterol greatly predates modern science, as the Maasai tribe in Kenya use a probiotic fermented milk in their diet. The Maasai diet is composed almost entirely of meat, milk and blood. This diet includes several times the recommended level of cholesterol, and yet the Maasai have no problems with atherosclerosis or other degenerative diseases that could be related to their diet. What has been found is that their fermented milk (no refrigeration, so it all gets fermented if not immediately consumed!) contains probiotic bacterial population s that help to consume and lower cholesterol. Other sources of probiotics, such as yogurt, have been found to lower cholesterol levels also. 

Many people incorporate yogurt into their diet because they like it or they think that it is healthy--but what makes it healthy? Much of the yogurt on store shelves has no bacterial colony whatsoever, so it is important to read the ingredients! If it has no "live active cultures," then it has little if any health benefit to our good bacteria and subsequent immune function.

Eggs have often been the poster child of high cholesterol food, if the yolk is used. However, consuming eggs may not have as much to do with elevated cholesterol level as initially thought. Similarly, fats were implicated in the disease process, as it has been observed that people with high triglycerides (fats) in their blood are at increased risk of developing heart disease. There are other variables in this equation, as is often the case. For example, abnormal populations of gut bacteria promote atherosclerosis by causing inflammatory changes and altered metabolism of lipids. The presence of abnormal gut bacteria that cause irritable bowel syndrome is directly linked to the development of thickening of the wall of arteries, which is of course the actual structural change that is at the center of what we call atherosclerosis.

Excerpt from The Symboint Factor by Richard Matthews DC DACNB FACFN

Healthcare: Treating the Symptoms and Not the Problem

We experience symptoms of illness (ie high blood pressure or dysbiosis)  as a sign that something within the body is not working as it should. The presence of symptoms should alert a person that the body has become imbalanced in some way, so that action can be taken to restore balance and function. Instead, most people are taught to treat the symptoms only. Examples would be taking pain relievers to control pain or using muscle relaxers for muscle spasms or even blood pressure pills and statin drugs to help with risk factors for heart disease. This unfortunately does not correct the underlying imbalance that caused the dysfunction and symptom to result. The true problem may continue creating imbalances in the body's system until more serious conditions manifest. 

There are few cases of "one cause, one cure" that happen in the human body. Pursuing health means maximizing the function of all the body's intrinsic systems as well as the brain. This is a completely different concept than what we usually encounter in healthcare. Often asked is the question: "will my insurance cover that?" when explaining health-building strategies, and the answer is almost always a "no." The reason is that insurance companies sell disease care policies, not health care policies. The number of pure health building interventions that are covered, if any, can often be counted on one hand. For example, does insurance cover nutritional supplements, gym memberships, yoga classes, new bicycles, probiotic foods, kitchen tools such as a VitaMix and similar items? Perhaps some of these are covered items in some countries, but not in the United States. Nothing that prevents cancer is covered, but annual early detection is, to see if your have it yet. The "system" is geared toward specific treatment for a specific disease, and yet almost all diseases have several factors or circumstances as causes. If a person falls and breaks a wrist, the doctor that treats that wrist has a very specific job. If the patient instead has arthritis and migraines, what are the causes? Inflammation, poor diet, biomechanical issues, lifestyle, genetics--four out of five of these are variables that we have control over and yet often do nothing about.

Adapted from The Symboint Factor by Richard Matthews DC DACNB FACFN

Avoid the Worst Ingredients

Flavor enhancers, preservatives, sweeteners, synthetic colors and manmade fats and chemicals commonly hide out in the ultra-processed foods we eat. If you want to stay away from putting harmful chemicals on your table, it’s necessary to learn how to identify the worst ingredients and find healthier alternatives. Let’s take a look at how to get started.

1. Identify and avoid these seriously dangerous additives

It’s not easy to remember all of the worst ingredients to steer clear of, but learning to avoid the most toxic ones commonly found in the food supply can drastically improve your health. A common food additive is monosodium glutamate (MSG) that is very dangerous and affects human body in a variety of ways. Headache, nausea, vomiting, pain in the back of the neck, numbness and heart palpitations are common side-effects of consuming MSG. Monosodium glutamate is an excitotoxin that overexcites the cells in your body to the extent where they are so heavily damaged that they die. MSG also leads to a range of neurological diseases on prolonged exposure. (1, 2)

It’s not easy to find processed foods that are completely free of MSG. Other food ingredients often mask the presence of MSG, including:

• autolyzed yeast
• hydrolyzed protein
• hydrolyzed vegetable protein
• sodium caseinate
• yeast nutrient or yeast extract
• Torulo yeast
• natural flavoring
• glutamic acid

Soy sauce, seasonings, powdered milk, stock, malt, maltodextrin, pectin and anything protein often contain MSG.

2. Avoid the toxic heart attack ingredient

Trans fats are very harmful. These artificial trans fatty acids lower the level of good cholesterol (HDL) and increase the level of bad cholesterol (LDL) in your body. Primarily used in processed foods, trans fats are formed when food manufacturers add hydrogen to liquid oil to solidify it. (They do this to increase shelf life.) Unfortunately, trans fats have been blamed for up to 50,000 premature heart attack deaths a year. (3)

In the hydrogenation process, oil is heated to an extremely high temperature of about 500 to 1000 degree Celsius. Hydrogenated oil is a fabulous preservative because all the natural enzymes are destroyed by the high heat, rendering the end product as an unhealthy sludge. If you see terms like hydrogenated oil, partially hydrogenated oil or fractionated oil on food label, do not buy the products.

3. Steer clear of metabolism-sinking sweeteners

Artificial sweeteners may seem like a good choice if you’re watching your calories, but science shows us it’s really one of the worst ingredients when it comes to your metabolic health. High-fructose corn syrup (HFCS) is a sweetener that leads to weight gain, heart complications and obesity.

Some artificial sweeteners result in headaches and mood swings as well. Aspartame, saccharin and sucralose are widely used artificial sweeteners and can exert a bigger load on your metabolic system than plain old sugar. They also trick your brain into feeling less full, prompting you to eat more, which in turn can lead to weight gain. So monitor your intake of artificial sweeteners to stay fit.

4. Beware of these 3-letter cancer causers

Butylated hydroxyanisole (BHA) and Butylated hydroxytoluene (BHT) are processed food preservatives that have been found to have carcinogenic properties by the International Agency for Research on Cancer. BHA has been declared safe by FDA, but it is termed ‘reasonably anticipated to be a human carcinogen’ by U.S. Department of Health and Human Services. (4, 5)

BHA has been shown to act as an endocrine disruptors, interfering with healthy hormone production, too. (6) BHA and BHT preservatives are commonly found in cereals, potato chips, chewing gum and cereal snack mixes. (Read your cosmetics labels, too. They often hide out in personal care products.)

5. Don’t assume soy is safer

Is soy bad for you? In the majority of cases, particularly as it pertains to soy as an ingredient in processed foods, it is unhealthy. While many of us think that soy and soy products as healthy and protein-rich, this is not always true. A majority of soy used in processed food products is genetically engineered. That means the crop has been tinkered with on a genetic level to receive applications of glyphosate, the main ingredient in Roundup weedkiller, without killing the plant. This has led to “excessive” levels of glyphosate turning up in the food we eat. (7) In 2015, the World Health Organization declared glyphosate “probably carcinogen to humans.” That makes conventional soy one of the worst ingredients.

Consuming GMO ingredients in considerable quantity over a long period of time is suspected to lead to infertility, gluten disorders, allergies and even cancer. Though the jury is still out on this controversial topic, with several studies showing that GMO ingredients are safe, I suggest practicing the precautionary principle, meaning it’s always best to consume processed foods that rely the least on GMO ingredients, staying as natural as possible. (8)

Factors in Non-Contact ACL Injuries

A short animation of typical conditions leading to a non-contact ACL injury.

Pre Workout Supplements: Hypertrophy Priority

Here are some supplement recommendations for athletes seeking to maximize Hypertrophy. With Hypertrophy we are trying to maximize the acidic environment to induce as much damage, cell swelling and hyperemia as possible. What can we take preworkout to help this along?

Primarily, we will want to look at things that shuttle nutrients and blood into the muscle. 

1. Citruline Malate: reduces fatigue and improves muscle endurance. More effective than Arginine. Arginine actually decreases GH during your workout when taken pre exercise. Arginine is best used before bed. 
2. Antioxidants : Alpha Lipoic Acid, grape seed extract and CoQ10 improve mitochondrial function and will allow for more blood flow to muscles during training.
3. Beet Root Powder: Vasodilator, will induce a pretty gnarly pump.
4. Neurotransmitter boosters: these will be important for anyone that has a hard time getting amped up to train. I advise against taking caffeine as a pre workout before Hypertrophy sessions because caffeine is a vaso constrictor. That means that taking caffeine with nutrients to chase the pump is a bit futile. There is a trade off for sure. If training without caffeine leads to a shit workout, then it may be worth your while to take caffeine instead of some of the vasodilators. Taking both at the same time though, to me, is a waste of money.
5. BCAAs: provides energy and will prevent muscle protein breakdown during training.
6. Creatine: will help sustain energy levels throughout your sessions and get more fluid into the muscles.

Why do partial squats not transfer very well to sport?

By Chris Beardsley, S&C Research columnist

Partial squats make you stronger at partial squats, but do not transfer to full squats. On the other hand, full squats make you stronger at full squats and also make you stronger at partial squats (although usually not quite as well as partial squats).

This is probably because the mechanisms that produce joint angle-specific strength gains are different after training at long muscle lengths, compared to training at short muscle lengths. Training at longer muscle lengths involves more regional hypertrophy, which seems to transfer better to strength across the whole range of motion.

Even so, many coaches have noted that the joint angles in partial squats are similar to the joint angles in the stance phase of running gait, or during jumping. Because of this similarity between joint angles, they suggest that partial squats should transfer better to sport than full squats, as they should produce the greatest gains in strength exactly where we need them.

And this makes a lot of sense.

On the other hand, most research shows that full squats are superior compared to partial squats for improving athletic performance in many respects, particularly jumping.

So what mechanism could be causing this disparity?

What is the background?

You should be able to follow this article without too many problems if you remember that we are normally stronger at one joint angle compared to all the rest, which we call the angle of peak torque.

This angle of peak torque can be changed in different ways, by different types of training.

Training programs using full ranges of motion, using long muscle lengths, or eccentrically all tend to move the angle of peak torque to a joint angle corresponding to a longer muscle-tendon length. In contrast, training programs using a partial range of motion, or short muscle lengths, tend to move the angle of peak torque to a joint angle corresponding to a shorter muscle-tendon length.

And most importantly, changing the angle of peak torque is very likely one of the main mechanisms that causes joint angle-specific gains in strength.

However, angles of peak torque are normally measured using isometric tests, and they might differ during dynamic contractions, particularly at higher speeds.

So does this happen?

Do angles of peak torque differ with angular velocity?

Full range of motion exercises might transfer better to sport than partial range of motion exercises if the angles of peak torque are different when we measure them at different speeds.

This will be particularly relevant if our exercises are traditional, heavy squats, as they involve much slower movement speeds than jumping or sprinting.

And this does happen!

The angle of peak torque is seen at joint angles corresponding to shorter muscle-tendon lengths as angular velocity increases (Moffroid et al. 1969; Knapik et al. 1983; Kannus & Jarvinen, 1991; Yoon et al. 1991; Khalaf et al. 1997; Khalaf et al. 2001; Khalaf & Parnianpour, 2001; Anderson et al. 2007; Ripamonti et al. 2008), although this effect is not always observed consistently in every study, and is much less marked above 180 degrees/s (Frey-Law et al. 2012).

The following charts derived from data reported by Yoon et al. (1991) show how the angle of peak torque alters with increasing angular velocity. Each line represents a different angular velocity moving through the same joint angle range of motion.

Here is knee flexion (contracting from left to right):

As you can see, as the movement speed increases, two things happen.

Firstly, the lines shift downwards, because force reduces as angular velocity increases (because of the force-velocity relationship).

Secondly, the angle of peak torque moves further to the right as angular velocity increases. This means that the angle of peak torque occurs at progressively shorter and shorter muscle-tendon lengths as angular velocity increases.

Here is knee extension (contracting from left to right):

Why do angles of peak torque differ with changing speed?

As you can see from the charts, the angle of peak torque moves to a joint angle that corresponds to shorter and shorter muscle-tendon lengths, with increasing speed.

This probably happens because even though the muscle-tendon lengths are the same at each joint angle, the muscle and tendon do not change length in the same way at different contraction speeds (don’t forget that tendons always lengthen to a greater or lesser extent when a muscle contracts, even when the contraction is purely a concentric contraction that involves a shortening of the muscle-tendon unit).

Fast contractions involve small muscle forces, which cause a smaller amount of tendon elongation at the start of the contraction.

The smaller amount of tendon elongation in fast contractions means that the muscle stays lengthened for longer in the concentric phase of the contraction. This allows the muscle to stay on the plateau of the length-tension curve for longer. Therefore, the angle of peak torque is shifted to much later in the overall joint angle range of motion (Murray et al. 1980).

Slow contractions involve high muscle forces, which cause much more tendon elongation at the start of the contraction.

This greater tendon elongation means that the muscle does not remain lengthened for very long during the concentric contraction. So it drops off the plateau of the length-tension curve quickly. Therefore, the angle of peak torque is seen earlier on in the overall joint angle range of motion (Murray et al. 1980). And isometric contractions are the slowest, strongest contractions of all.

Why is this important?

Why is contraction speed important for the angle of peak torque?

There are two key implications.

Firstly, it means that the angle of peak torque in dynamic movements is always at joint angles corresponding to shorter muscle-tendon lengths compared to the isometric angle of peak torque.

Secondly, it means that sporting movements at very high angular velocities have angles of peak torque at joint angles corresponding to very short muscle-tendon lengths. However, even when measured in the same person, these are not the same angles of peak torque as slower, barbell exercises or isometric tests. Those angles of peak torque occur at much longer muscle-tendon lengths.

This may be why full range of motion heavy resistance training exercises transfer better than similarly-loaded partial range of motion exercises to many high-velocity athletic movements.

What does this mean for jumping?

The quadriceps are key for jumping, and most jumping requires an angle of peak torque at moderate quadriceps lengths, as neither jumpers nor team sports athletes bend their knees down to the levels seen during a full squat before take-off.

This has led some coaches to assume that partial squats might be helpful, as they seem to involve a peak contraction around the same sort of joint angle.

But although this sounds logical, it ignores how the angle of peak torque changes with movement speed.

During a slow, heavy squat, the angle of peak torque will be observed at long muscle lengths. On the other hand, a jump is clearly a very fast movement and so the corresponding angle of peak torque will be at a much shorter muscle length.

If we train at long quadriceps muscle lengths, such as in the deep squat, we shift the angle of peak torque towards a longer muscle length. Because increasing movement speed moves angles of peak torques towards shorter muscle lengths, however, this will correspond to an angle of peak torque at moderate muscle lengths when we measure it at a fast velocity.

This is exactly where we need them for the jump.

If we train at short-to-moderate quadriceps muscle lengths, such as in the partial squat, we shift the angle of peak torque towards a shorter muscle length. Because increasing movement speed moves angles of peak torques towards shorter muscle lengths, however, this will correspond to an angle of peak torque at very short muscle lengths when we measure it at a fast velocity.

This is not where we want them for the jump.

And this is why deep squats transfer much better to jumping than partial squats (Weiss et al. 2000; Hartmann et al. 2012; Bloomquist et al. 2013).

Although there is less research available for sprinting, the same principles will apply.

Conclusions

Some people have proposed that partial squats should transfer better to sport than full squats because of the similar joint angles involved. However, full squats are definitely superior, and this is very clear in relation to jumping.

The reason for this discrepancy is that the angle of peak torque changes with movement speed. The angle of peak torque is found at shorter muscle-tendon lengths when measured at fast speeds, compared to when measured at slow speeds.

This is likely because even though the muscle-tendon lengths are the same at each joint angle, the muscle and tendon do not lengthen to the same extent at different speeds, and the amount of tendon elongation is less during fast contractions, which allows the muscle to remain on its length-tension plateau for longer.

Heavy, slow exercises such as full squats produce peak contractions at long muscle-tendon lengths. Because of differences in the amount that the tendon changes length, these angles of peak torque correspond very well to the peak contractions in athletic movements at joint angles corresponding to shorter muscle-tendon lengths, such as in jumping.

References

1. Anderson, D. E., Madigan, M. L., & Nussbaum, M. A. (2007). Maximum voluntary joint torque as a function of joint angle and angular velocity: model development and application to the lower limb.Journal of Biomechanics, 40(14), 3105-3113.
2. Bloomquist, K., Langberg, H., Karlsen, S., Madsgaard, S., Boesen, M., & Raastad, T. (2013). Effect of range of motion in heavy load squatting on muscle and tendon adaptations. European Journal of Applied Physiology, 113(8), 2133-2142.
3. Frey-Law, L. A., Laake, A., Avin, K. G., Heitsman, J., Marler, T., & Abdel-Malek, K. (2012). Knee and elbow 3d strength surfaces: peak torque-angle-velocity relationships. Journal of Applied Biomechanics, 28(6), 726-737.
4. Hartmann, H., Wirth, K., Klusemann, M., Dalic, J., Matuschek, C., & Schmidtbleicher, D. (2012). Influence of squatting depth on jumping performance. Journal of Strength & Conditioning Research, 26(12), 3243.
5. Kannus, P., & Jarvinen, M. (1991). Knee Angles of Isokinetic Peak Torques in Normal and Unstable Knee Joints. Isokinetics and Exercise Science, 1(2), 92-98.
6. Khalaf, K. A., Parnianpour, M., Sparto, P. J., & Simon, S. R. (1997). Modeling of functional trunk muscle performance: Interfacing ergonomics and spine rehabilitation in response to the ADA.Journal of Rehabilitation Research and Development, 34(4), 459.
7. Khalaf, K. A., Parnianpour, M., & Karakostas, T. (2001). Three dimensional surface representation of knee and hip joint torque capability. Biomedical Engineering: Applications, Basis and Communications, 13(02), 53-65.
8. Khalaf, K. A., & Parnianpour, M. (2001). A normative database of isokinetic upper-extremity joint strengths: towards the evaluation of dynamic human performance. Biomedical Engineering: Applications, Basis and Communications, 13(02), 79-92.
9. Knapik, J. J., Wright, J. E., Mawdsley, R. H., & Braun, J. (1983). Isometric, isotonic, and isokinetic torque variations in four muscle groups through a range of joint motion. Physical Therapy, 63(6), 938-947.
10. Moffroid, M., Whipple, R., Hofkosh, J., Lowman, E., & Thistle, H. (1969). A study of isokinetic exercise. Physical Therapy, 49(7), 735.
11. Murray, M. P., Gardner, G. M., Mollinger, L. A., & Sepic, S. B. (1980). Strength of Isometric and isokinetic contractions knee muscles of men aged 20 to 86. Physical Therapy, 60(4), 412-419.
12. Ripamonti, M., Colin, D., & Rahmani, A. (2008). Torque–velocity and power–velocity relationships during isokinetic trunk flexion and extension. Clinical Biomechanics, 5(23), 520-526.
13. Weiss, L. W., Fry, A. C., Wodd, L. E., Relya, G. E., & Melton, C. (2000). Comparative Effects of Deep Versus Shallow Squat and Leg-Press Training on Vertical Jumping Ability and Related Factors. The Journal of Strength & Conditioning Research, 14(3), 241-247.
14. Yoon, T. S., Park, D. S., Kang, S. W., Chun, S. I., & Shin, J. S. (1991). Isometric and isokinetic torque curves at the knee joint. Yonsei Medical Journal, 32(1), 33-43.

Is physical strength a virtue?

Judging by the way so many people revere elite athletes, it seems arguable that physical strength is a virtue in the ancient sense of that word, i.e. a human excellence, or an excellence in a human being who possesses it. Or at least it is commonly regarded that way.

That’s controversial enough, but could it even be an excellence with moral or ethical significance? That sounds like a very strange notion to modern ears, but Aristotle would (arguably) have thought so, and the idea can be developed as part of a sophisticated ethical theory that deals with at least the most obvious objections on the ground of absurdity, etc. This would obviously have consequences for current debates about human enhancement technologies.

In the current issue of The Journal of Evolution and Technology, Kyle Oskvig broaches this tricky subject. He does not offer a full defense of Aristotle, but he does show that an evolved, reconstructed version of Aristotelian ethics can make such ideas seem much less crazy than we moderns are inclined to think. Check it out!

12 Clinical Pearls from Dr. Rakowski

1. People who thrive are the ones that make and metabolize acids correctly. Acid can be your friend if you manage it properly.

2. Here is a pearl from Dr. Rakowski, he showed a scientific paper on B12 absorption and brain aging. If you don't absorb B12, your brain ages 617% faster! As I have stated before, the greatest impact of not testing your HCl levels is compromising your brain health.

3. Growth hormone is a significant anti-depressant. Deep sleep is the real way to achieve optimal growth hormone levels.

4. The major benefit of using Arginine is boosting growth hormone during effort, besides boosting NO2.

5. Only fat people make too much estrogen.

6. People who have elevated triglycerides have low levels of growth hormone.

7. The body ignores constant stimuli. Changing everything constantly is one of the keys to success whether we are talking about training, diet, or supplements.

8. Brain derived neurotrophic factor is a strong anti-depressant produced by exercise that induces lactic acid production.

9. Learning improves 20% after exercise. Why are we canning Physical Education classes?

9. Charlie Chaplin fathered a child when he was 80. Sexual dysfunction is rampant because people are simply unhealthy.

10. Low-grade systemic inflammation (metaflammation) is associated with obesity, insulin resistance and chronic disease (Brithish Journal of Nutrition (2009)  102, 1238-1242

11. Friends do not let friends get fat.

12. Sleep is your most powerful anti-inflammatory agent

Chocolate Milk For Post-Workout: A Look at the Research

Over recent years, there has been a massive initiative to promote chocolate milk as “the best” drink for post-training recovery. Milk advertisers use very high level athletes as spokespersons to sell a product to people who are indeed active, but often very far from the training level of an Olympic athlete.

Nautilus Plus is participating to this initiative: “Whether you are a professional athlete or a weekend sports enthusiast, recover from your next training faster with the Ultimate Chocolate Milk®.”(1) Do we really need to fill ourselves with all this added sugar after our training?

One litre of chocolate milk contains up to 100 to 110 g of sugar!!! The quantity of sugar that the body can absorb is limited. In fact, the sugar will be stored in the liver and muscles in the form of glycogen, which only represents 5 % of the body’s total energy reserves (2). If your objective is, as for the majority of people, to lose fat, you need to remember this: to allow yourself to consume a supplement rich in carbohydrates after your training, you will have to have emptied or seriously depleted your glycogen stores in order for the extra sugar absorbed to be used to renew your glycogen stores. And if you absorb more sugar than you need to renew your reserves, it will be transformed into fat (3).

Scientific studies

Many scientific studies have been done on sports nutrition supplements and some included chocolate milk. The purpose of these studies was to determine which mixture of molecules, and in what proportion, best promotes post-training recovery as well as athletic performance. Almost all these studies followed this particular protocol:

1.  Study participants were subjected to intense exercise at 70 to 85% of their VO2 max during 1 to 3 hours. The purpose of this step was to considerably reduce the muscle and hepatic glycogen stores since 70 to 80% of the energy spent at 85% VO2 max is derived from glycogen. Under 65% of VO2 max, mostly fatty acids are used (4, 5).
2. A recovery period between 4 and 8 hours followed to allow the participants to replenish their glycogen stores with the various sports nutrition supplements covered in the study.
3. Participants were then subjected to a second high intensity exercise (VO2 max between 70 and 85%) until exhaustion (loss of 85 to 95% of their hepatic glycogen and 65 to 85 % of their muscle glycogen) (6). The difference in time or distance between the performances will determine which sports nutrition supplements helped the athlete the most to recuperate between the two sessions.
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The role of these sports nutrition supplements is therefore to replenish as quickly and efficiently as possible the glycogen stores which were SIGNIFICANTLY depleted during the first training, in order to allow a second intense performance within 4 to 8 hours.

This situation is certainly frequent among Olympic athletes or athletes from the Tour de France who train several times per day or several days in a row at extreme intensities, but what about other people? Is chocolate milk a good supplement for “weekend athletes” or people who train leisurely, three of four times per week?

After your leisure strength training?

For a person who does resistance strength training, the glycogen stores will fall by 25 to 40 % after an intense strength training (7 to 12), which is relatively little. The glycogen stores lost during the training will be rebuilt through normal nutrition, WITHOUT ANY SUPPLEMENTS, within 24 hours of the training. However, some people consider it very important to MAXIMIZE the production of lean muscle mass. So the rapid intake of PROTEIN supplements after the training (within 1 hour if possible, up to 3 hours later) is important since it promotes maximum muscle synthesis(13 to 33). Recently, a research team questioned this principle claiming that it would be the total quantity of proteins ingested each day that would prevail over the moment at which they are ingested (34, 35). The same team also mentioned that if a “window” for taking a protein supplement and maximizing the production of lean muscle mass does exist, it would rather span over a 4 to 6 hour period following the strength training.

According to various recent studies, 20 to 25g of proteins would be the recommended amount to take after a resistance training (25, 33, 36). Witard et al., 2014 consider that 20 g of whey protein containing approximately 2 g of leucine optimally stimulates muscle synthesis (33). A litre of chocolate milk contains approximately 30g of proteins, including 80% of micellar casein and 20% of whey (37). Studies on post-training muscle synthesis clearly show the very poor efficiency of micellar casein for this purpose (26, 28, 38, 39, 40) because it precipitates in the stomach and the absorption of amino acids responsible for muscle synthesis is therefore very slow (26, 41, 42, 43). One argument that is often used by chocolate milk advocates is that milk (skim) is more efficient than soy protein or casein to promote muscle synthesis (23, 24). That’s true! It is actually the 20% of whey proteins contained in the milk that makes it efficient for muscle regeneration (26, 28, 40). What they don’t say is that purified whey protein (concentrate or isolate) is the best all around for lean muscle mass gain (26, 28, 40, 44, 45, 37) and, consequently, is better than milk. Whey protein is very rich in BCAA and is quickly absorbed by the intestine, as opposed to casein which is absorbed slowly. Therefore, why take a milk supplement if a whey protein shake is more efficient? Not only does chocolate milk contain large quantities of casein, but it can also contain saturated fat (if it’s full fat) as well as a large quantity of added simple sugars, on top of the lactose. So, is it useful to add all this sugar to the proteins (which are already not optimal) to maximize muscle synthesis after my resistance training?

Some studies show that carbohydrates (CHO) could inhibit muscle breakdown caused by training (10, 46, 47, 48, 49). A few groups claim that a carbohydrate/protein (CHO:PRO) supplement would facilitate a better muscle synthesis since it would inhibit muscle breakdown (15, 32, 46, 48, 50, 51). Nevertheless, some of these studies did not include a control group for the proteins (PRO) only. So it is difficult to evaluate whether adding CHO to PRO provides an advantage or not over PRO taken separately. As for the few studies that included a control group for the PRO, the quantity used was sub-optimal and was given in the form of amino acids (46, 48, 50). However, when a control group taking PRO optimally is included in the study, adding CHO to PRO did not show any advantage in terms of lean muscle mass gain (49, 52 to 57). CHO: PRO ratios used in the studies on resistance training varied between 1:1 and 3:1 whereas chocolate milk offers a ratio between 3:1 and 4:1. That is a lot of unnecessary sugar!

In turn, adding CHO to protein supplements can be necessary when several INTENSIVE resistance trainings are planned during the same day. In such a case, the athlete must quickly renew its glycogen stores (58, 59). To this end, 1g/kg of weight of CHO should be added to the proteins and consumed immediately after the training; moreover, a meal should follow 2 hours after the training (59, 60). So you must weigh at least 220 lbs and must train intensely more than once a day to allow yourself a litre of chocolate milk. Even then, you won’t achieve optimal results because of the casein, which constitutes 80% of the total proteins, and because of the 2:1:0.46 (glucose:fructose:galactose) ratio of the various sugars present in the chocolate milk (61).

The fructose contained in chocolate milk comes from high fructose corn syrup (which has a very bad reputation) and from sucrose (1 glucose +1 fructose). In 2004, Bray GA et al. suggested that the obesity epidemic in the United-States was related to the HFCS found everywhere and in large quantities in our nutrition (62). However, the new report published by The International Journal of Obesity, 2015 (63) suggests that this epidemic cannot be linked to HFCS due to the lack of evidence demonstrating that HFCS would be worse than table sugar (sucrose) (63, 64, 65). Yet, chocolate milk contains both of these additives. The fructose contained in almost equal quantities in both these additives could be linked to obesity (66, 67). Some scientists are reluctant to establish such a link (63, 64). A small quantity of fructose consumed every day, such as normal consumption of fruits, is harmless. Unfortunately, fructose is now added in almost all processed food. So it’s easy to exceed the healthy daily quantities of “natural” fructose. The body metabolises fructose differently from glucose. The liver metabolises 70% of the blood fructose (compared to 15 to 30% for the glucose) (38) and will leave the remaining 30% to the other tissues, namely the kidneys, the testicles, the fatty tissues, the brain and the skeletal muscle (69). So the muscles will absorb a negligible amount of fructose (68). A large consumption of fructose can contribute to the development of the metabolic syndrome, consisting in weight gain, increased resistance to insulin, hypertension, and elevated triglyceride in the blood stream (67, 69). High quantities of fructose are also associated to increased cholesterol, LDL particles and visceral obesity (69).

After an intense cardiovascular training, such as a marathon, when the glycogen stores in the liver are low, the fructose present in a sports nutrition supplement will be used to replenish the hepatic stores. Furthermore, for marathon runners performing at high intensities for a long period of time, the intake of fructose in the form of supplements DURING performance at a ratio of 2:1 (glucose/maltodextrin:fructose), offers a definite advantage because it allows faster absorption of sugars through the intestines since different transporters are used for these two sugars. The supplement would also improve gastro-intestinal comfort and would increase these athletes’ performance (70 to 76). If, however, the quantity of fructose consumed is higher than what is needed to replenish the hepatic stores, the surplus could potentially be converted into fat (66). So for people who do resistance training, consuming fructose is of no value. Conclusion? If you need CHO to perform well during your second strength training, you should add glucose/maltodextrin to your whey proteins, in order to avoid consuming fructose unnecessarily.

Finally, at the beginning of 2015, Stuart M. Phillips’ team established that drinking 500ml of chocolate milk every day (18g of proteins) as a supplement, while following a resistance program three times per week over a period of twelve weeks, has no effect on muscle hypertrophy or on strength gain compared to a control group taking no supplements (77).

What about after leisure endurance training?

Many active people do endurance training several times per week such as jogging, spinning, swimming, etc. for one hour. The extent of the muscle and hepatic glycogen loss will vary according to the effort expended. To consume glycogen as a primary source of energy, the level of effort intensity must reach 70% and must be maintained for an extended period of time (4, 5, 78). Laboratory experiments have shown that glycogen stores decline by 50 to 75% after 3 hours of cycling at 70% of VO2max (79, 80). By increasing the effort to 80% of VO2max, you can continue your activity for 2 hours before running out of glycogen. Another example is that the glycogen stores depletion of marathon runners occurs, for 40% of them, around the 34th kilometre, commonly called “the wall”, when they sustain an effort of approximately 80% of VO2max(81, 82, 83) during more than 2h30. Do you think you will be burning as much glycogen during your hour of spinning?

The glycogen stores lost during the training, even if this loss is significant, will be rebuilt through normal nutrition, WITHOUT ANY SUPPLEMENTS, within 24 hours of the training  (84,85). Moreover, the meal frequency will have no incidence if the post-exercise recovery happens over more than 24 hours (85, 86, 87). It is unnecessary for someone coming out of an hour of spinning or jogging to ingest all the added sugars contained in chocolate milk since the subsequent meals will contain sufficient carbohydrates (CHO) to replenish the poorly depleted glycogen stores. Therefore, the person will be ready for the next training a few days later.

Without being Olympic athletes, some people will train intensely and frequently during a week. In such case, the quantity of CHO these people consume every day must be adjusted, spread throughout their meals according to the frequency and intensity of their training. Burke et al. 2011 recommend to take a quantity of CHO every day, depending on the type of training performed (intensity and duration) to allow for a good glycogen resynthesis during the 24 hours following the training (88).

If the objectives of the person doing endurance training don’t include maximum muscular development, the muscle regeneration following an effort, namely the replenishment of glycogen stores, will occur normally with the proteins contained in the subsequent meal, when taken in sufficient quantity.

Supplements are necessary when training sessions are very intense and close together (a few hours) and require to quickly replenish the glycogen stores (in less than 24 hours).

What about high level athletes? (1.3% of the American population are athletes and of which 0.006% are professional athletes) (89).

Although chocolate milk is not intended for Olympic athletes, choosing such athletes as spokesperson to promote chocolate milk as a post-training supplement is almost an obligation; indeed, practically only these athletes could ultimately use chocolate milk as a sports nutrition supplement. Moreover, most studies carried out on the subject are done in a top level training context. But is chocolate milk, as alleged by the television commercials, a good choice for this 1% of the population ?

The purpose of a supplement is to promote fast recovery between two trainings done very close together, mainly by QUICKLY regenerating the glycogen stores. So the muscle glycogen resynthesis speed is important. It was established that this synthesis is faster when CHO are taken right after the training (90, 91, 92) and can be maintained during 6 hours with frequent intake of this supplement (69, 90, 93). Delaying the intake of CHO by 2 hours decreases the resynthesis speed by 50% (16,90). This is particularly important for a fast recovery but is unnecessary for recovery over 24 hours or more (87). OPTIMALLY, the quantity of CHO should be 1.0 to 1.2g/kg of weight/h (94, 95, 96), consumed at 15 to 30 min intervals (97). At this volume and frequency, CHO alone are sufficient to ensure an optimal glycogen synthesis. Sure! But chocolate milk doesn’t only contain CHO!

Is it useful to add proteins to CHO? (98)

To determine which supplement is the best one, we need to compare the different supplements. It is difficult to compare the studies that analyze the effect of adding proteins to a CHO supplement because several variables differ: 1) intensity (% of VO2max) and duration of the first exercise that aims at reducing the glycogen stores 2) choice of exercise (jogging or cycling) 3) various types of supplements consumed (isocaloric or not, as well as the chosen sugars and proteins) 4) control groups used (lack of placebo or other control groups) 5) carbohydrates:protein ratios (CHO:PRO) will vary between 2:1 (Berardi et al. 2006/2008) (99, 100) and 6.2:1 (Betts et al. 2005) (101) 6) duration and intensity of the second performance (% of VO2max).

Nonetheless, it’s possible to draw certain conclusions.

1: Importantly, the drinks studied must be isocaloric (must contain the same amount of calories) :

Some studies show a performance improvement post-recovery when proteins (PRO) are added to CHO versus a control group taking only CHO (102 to 105). However, the quantity of calories between the two drinks was not adjusted, so it wasn’t possible to determine if the performance improvement could be attributed to the addition of proteins or to the aaddition of energy.

2: It is important to compare the CHO+PRO supplement to a control group taking CHO optimally (1.0 to 1.2g/kg of weight/h) AND which is isocaloric:

Some studies show that the addition of proteins to the CHO supplement improves the second performance when compared to a control group taking a CHO only supplement. But this supplement was given sub-optimally during recovery (96, 102, 104, 106, 107). When the control group took the CHO supplement OPTIMALLY, the studies did not show any improvement in the second performance when proteins were added to the mix, even with variable ratios. (95, 96, 101 to 115, 116). A study showed, however, an advantage (100) (see the “Ratio” section).

So the athlete can chose between taking a mix of CHO + PRO, when it is impossible to optimally take a CHO supplement during recovery (1.2g/kg/h every 30 min during 3 to 4 hours) (94, 95, 96, 117). This indeed makes for a lot of CHO to ingest. But at which ratio must the athlete take its proteins?

3: Ratio

Advocates of chocolate milk allege that a ratio of 4:1 is best to support athletic recovery. This belief comes from one of the early studies done on the subject and which showed that a sports nutrition supplement, Endurox R4, containing 4:1 CHO: PRO offered a performance advantage when compared to a control group taking CHO, namely Gatorade (102). However, Endurox R4 contained two and a half times more CHO than Gatorade, in addition to the whey proteins, which gave it almost four times more calories than the Gatorade supplement consumed SUB-OPTIMALLY by the participants. It is obvious that in these conditions, Endurox R4 improved performance compared to Gatorade given the significant difference in CHO and energy consumed between the two drinks. Since the ratio used in this study was 4:1, which is the same as the chocolate milk ratio, the dairy industry took the opportunity to pretend it was the best ratio. Nonetheless, research continued and more recent studies show that ratios containing less sugar are as efficient, if not more, than a 4:1 ratio. Berardi et al. 2008 show an advantage on the second performance with the CHO: PRO mix at a ratio of 2:1 (CHO: 0.8kg/kg/hand PRO: 0.4kg/kg/h), over the control group taking the CHO supplement optimally (100, 117). So why add more sugar than necessary with a ratio of 4:1 if it offers no advantage?

Studies done on chocolate milk (McLellan TM et al. 2014 (98)) :

There are 5 major studies comparing chocolate milk to a few other sports drinks during a short term recovery between two performances. (118, 119, 120, 121, 122)

• None of these 5 studies explained how the chocolate milk taste was reproduced for the control groups. If the athletes know which type of supplement they are given, it can certainly influence the results; in such a case, the study is no longer “blind”.
• Some studies did not include a placebo or a sub-optimal CHO supplement for the control group (118, 122).
• 4 studies on 5 did not administer the supplement optimally (118, 119, 120, 121). The fifth study did so for the first recovery hour only (122).
• Pritchett et al. 2009 show that chocolate milk (3.8:1) offers no advantage for the second performance over Endurox R4 (3.8:1, isocaloric and same quantity of CHO) (118).
• The other four studies indicated that chocolate milk presented an advantage for the second performance compared to the other drinks studied (119, 120, 121, 122). On the other hand, the studies also present other shortfalls:

For Karp et al. 2006 and Thomas et al. 2009, the glycogen stores reduction protocol was not standardized during the first training(119, 120). That means that the energy expenditure varies a lot from one person to another, even for each individual, from one training session to another. So some groups used more glycogen than others before starting the recovery phase. For Karp et al. 2006 for example, (similar to Thomas et al. 2009), the chocolate milk group (60.8 min) had trained 16% less than the CHO + PRO control group taking Endurox R4 (72.6 min), but equally to the Gatorade group (sub-optimal). These differences can explain the superior performance of the chocolate milk group during the second training. Furthermore, we must report that the study by Karp et al. 2006 was partly financed by the Dairy and Nutrition Council Inc (119).

In the study by Lunn et al. 2012, chocolate milk is compared to a control group taking CHO optimally during the first hour of recovery (122). Despite the fact that the regeneration of the glycogen stores was equal between the two groups, the performance of the chocolate milk group was superior to that of the CHO control group during the second performance (difference of a few seconds). However, the intensity of the second performance was at 100% VO2max and lasted a very short time (203 vs 250 sec). In these very high intensity and very short duration conditions, the more or less important level of muscle glycogen stores before the effort don’t seem to influence performance (123, 124, 125, 126), as opposed to a lower intensity and longer duration performance. So optimally replenishing the glycogen stores is probably not that important in this case. Even the authors admit that the type of test used and the inability to mask the taste of the chocolate milk may have influenced the results. The authors challenge this by emphasizing that the purpose of their study was to show that chocolate milk promotes a better muscle synthesis compared to CHO alone (122). Milk contains proteins whereas the CHO of the control group contained none. So it is not surprising that the results show that chocolate milk increases muscle synthesis. A control group also taking proteins would have certainly given results similar to the chocolate milk, and possibly even better results if whey protein would have been used.

 The study by Furguson-Stegall et al. 2011 compared a chocolate milk ratio smaller than 3:1 to an isocaloric CHO drink and to a placebo (water) (121). The drinks were given sub-optimally. The performance of the chocolate milk group was superior by a few minutes during the second training (40km of cycling) compared to the CHO control group. Nonetheless, the glycogen resynthesis was better with the CHO control group, a result that is slightly contradictory. This study was financed by a Chair established by The National Dairy Council, as well as The National Fluid Milk Processor Promotion Board.

Therefore, the contradictory results, the lack of control groups, the questionable protocols and the inability to obtain blinded studies, do not allow to claim without any doubt that chocolate milk is the best supplement compared to the other supplements studied. The number of serious studies on chocolate milk will have to be considerably larger. Furthermore, these studies will have to be done more independently (not financed by the dairy industry, for example) to achieve more conclusive results.

It should be noted that chocolate milk has not been compared to a supplement offering a ratio of 2:1 previously shown to offer better performances than a CHO supplement taken optimally by Berardi et al. 2008 (100). For comparison purposes, a 200lbs (90kg) man who ingests a supplement offering a ratio of 2:1 will consume 72g of CHO/h instead of 85g/h for a chocolate milk supplement taken optimally. So this represents approximately 40g less of added sugar consumed, during a 3 hour recovery, to achieve the same result, if not better.

The composition of the supplement used by Berardi et al. 2008 is also very different from that of chocolate milk; it contained 33% of maltodextrin, 33% of glucose and 33% of whey (100). So in addition to the ratio, the choice of nutrients is important.

4: CHO

Maltodextrin (MD) seems to be the ideal sugar for muscle glycogen resynthesis after an intense effort. Piehl-Aulin et al. 2000 have shown that a supplement containing very high molecular weight polyglucosides such as maltodextrin would be 25% more efficient for muscle glycogen synthesis than a low molecular weight glucose, maltose or oligomer supplement (127). This would be due to the faster absorption rate of sugars by the intestines, as well as an increased rate of gastric emptying. As seen previously, while the addition of fructose to MD (ratio 2:1, MD: FRU) represents a major advantage DURING a long performance (more than 2h30) such as a marathon(128), it seems that for the rapid muscle glycogen resynthesis between two performances, the addition of fructose or galactose to MD offers no advantage (129). Regarding sucrose (glucose: fructose), no advantage was observed concerning glycogen resynthesis when compared to glucose alone (69, 129, 130, 131, 132), nor during the second performance (129 to 131). Again, we notice that the fructose and galactose portion found in chocolate milk is not useful for the post-training recovery.

5: Proteins

As for strength training, the type of proteins added to the CHO as a post-training supplement is important. However, few studies compare the different types of proteins and their effects on the glycogen resynthesis speed during a short term recovery. Morifuji et al. 2010 have shown, in rats, that adding whey hydrolysate to CHO is more efficient for glycogen synthesis than the CHO control group, followed by non-hydrolysed whey and BCAA. Casein ranked dead last, having no significant effect on glycogen synthesis compared to the intake of glucose alone (133). A large proportion of studies on athletic recovery used hydrolysed or non-hydrolysed whey protein isolate as a source of proteins in their mixes. The advantage over the chocolate milk proteins (mainly consisting of casein) is that in addition to being absorbed faster, the whey protein allows a higher protein concentration mix while restricting the volume to be consumed. It is a non-negligible advantage for the athletes as well as for achieving ratios of 2:1, for example.

Lactose

Milk contains 25g of lactose per 500ml. The capacity to break down lactose into glucose and galactose molecules depends on the presence of the lactase enzyme in the small intestine. “Normally” in humans, the presence or activity of lactase is very strong at the beginning of childhood and starts declining after the child is weaned until it almost disappears in adulthood. The person is then unable to digest lactose for the rest of his or her life (134, 135, 136). Between 65 and 70% of the world population is unable to digest lactose once they reach adulthood (137, 138). So only 30 to 35% of the population can actually digest lactose. Why? During the human evolution, four different mutations occurred, namely a major one that occurred in Europe, which kept the lactase gene active and thus allowing some Caucasians to digest lactose during all their life(137 to 139). These European Caucasians travelled, reached America and gave their descendants the possibility to also carry this mutation. Despite this, approximately 21% of North Americans who have problems digesting lactose are Caucasians (140). The ability to digest lactose is directly linked to the quantity of lactase produced by the intestine (134 to 136) and this quantity varies from one person to another. So some people have more difficulty than others to digest this sugar even though it may not be a true intolerance, rather an incomplete digestion that can sometimes be asymptomatic (140 to 143).

Making up 50% of the sugar contained in chocolate milk, we must seriously question the lactose digestion capacity to quickly regenerate the glycogen stores post-training, if we take into account the differences in the quantities of lactase present in the intestines of each individuals. It was shown that adding sugar (144, 145, 146, 147), fat (147) or chocolate (144, 145) in milk slows down the digestion process. This slowing down certainly promotes a better digestion of the lactose by the lactase present in various amounts, but does make digestion more efficient ? Since it can be very difficult for some people, around the world, to digest lactose, chocolate milk could only be used by a very small portion of athletes, which already represent a tiny portion of the population.

Who promotes chocolate milk?

Besides dairy producers in Quebec and Canada, many nutritionists promote chocolate milk as an ideal post-training supplement. The most relevant comment made to this effect by a nutritionist is the comment from Isabelle Charêt, coach and triple medallist in speed skating at the 1994, 1998 and 2002 winter Olympics (148). She says that chocolate milk would be a lot more useful to people who train intensively: “Someone who goes to the gym three times a week has plenty of time to recover. But I still recommend to drink chocolate milk because people in general don’t drink enough milk.” Ah! But that’s the issue! We have to drink milk!

I will not go into further detail on this subject, but very recently (2013), a team from Harvard University acknowledged publicly the need to decrease to less than two portions per day, or to stop all together, our milk consumption (149, 150). The powerful dairy industry lobby, which represents a third of Quebec’s agriculture and 5 billion dollars of Canadian GDP, imposed itself to maintain the dominant position dairy products hold in the Canadian food guide (151). Nonetheless, the following question remains: is it necessary to include chocolate milk in our diet? Many scientists seem to think that it’s not (149, 150, 151, 152).

Conscious of the extent of the damages caused by the overconsumption of added sugars to human health, how can we encourage the consumption of such sugars just to impose a supplement that is increasingly considered as unnecessary to our health?

Conclusion? If you enjoy a glass of chocolate milk once in a while, as a treat, it’s no big deal! But if milk commercials encourage you to drink one after each of your trainings, and you are not an Olympic athlete (and even then…), I hope you’ll think twice about it.

You know the saying: When it seems too good to be true…

References :

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Tips for Optimal Leanness

#1: Take Control of What You Put In Your Mouth

When people let their emotions drive their eating, they end up feeling out of control and always hungry. Instead, try making informed choices about what and how you eat. By taking control of what you put in your mouth you avoid the pitfalls of emotional eating and can be empowered by your decisions.

#2: Get Fat Adapted

Most people don’t have the metabolic machinery to effectively burn body fat. Instead they run on carbs all day. The solution is to restrict carbohydrates in favor of protein and fat for your first two meals of the day (or at least for breakfast) in order to force the body to fat. Anaerobic exercise such as weight lifting or sprinting will also improve your body’s ability to burn fat.

#3: Eat The Most High-Quality Proteins—10 Grams of EAAs At Every Meal

High-quality protein includes fish, meat, poultry, eggs, and Greek yogurt. Planning meals around these foods blunts appetite and keeps you full, while also preserving lean mass during fat loss;. Protein also keeps blood sugar steady and and increases resting energy expenditure because protein is the most metabolically costly food for the body to digest.

#4: Ruthlessly Take Care of Your Gut Health

The microflora that live in your gut play a pivotal role in establishing your body composition, cholesterol profile, and long-term heart health. Support it by eating foods with fermented probiotics and lots of plant foods. Studies of groups that eat traditional diets have excellent gut health due to the high intake of root tubers, leafy vegetables, fruit, and nuts.

#5: Eat Fats That Are Good For You

Healthy fats are necessary for optimal hormone function and they provide bioavailable nutrients that will support a lean, muscular body composition.  They are also delicious and filling. Good fats include those from olive and coconut oil, nuts, avocados, eggs, dairy, wild fish, and organic meat.

#6: Eat. Real. Food.

Most processed foods are engineered to trigger food intake and make you eat more calories. Processed foods also have a lower thermic effect than whole foods, meaning that if you eat a processed meat sandwich with white bread, your body will burn fewer calories during digestion than if you ate the same amount of calories from chicken breast, rice, and sweet potatoes.

#7: Favor Plants Over Grains.

Favoring vegetables instead of grains is an easy way to fill you up and increase nutritional density, but with fewer calories. Grain-based foods, whether it's good bread, crackers, rice, or cereal are very easy to overeat and they tend to crowd out other more nutritious foods.

#8: Save Higher Carb Foods For Dinner/Post-Workout

After working out your muscles are starving for nutrition. They are extra sensitive to insulin so that any carbs you eat will be stored as glycogen instead of fat. This makes post-workout the perfect time to enjoy higher carb foods. Further, including complex carbs at dinner will help lower cortisol and raise serotonin for restful sleep.

#9: Invest In Organic Meat, Eggs & Dairy

Organic meat, eggs, and dairy are significantly more nutritious than conventional versions and they help you avoid growth hormones and pesticides that may have estrogenic activity. High chemical estrogen intake is associated with higher body fat and worse health.

#10: Strength Train & Do Sprints—Proper Exercise Makes Everything Better

Don’t let lack of exercise be your blind spot. Exponentially greater benefits will come if you combine training and the optimal diet. Find a way to make it fun so that you enjoy movement—it’s what you were put on this earth to do!

The Promise of (Omega-3) DHA

From heart disease to joint pain, the conditions shown to benefit from increased omega-3 fatty acid intake are diverse. The cardioprotective and anti-inflammatory benefits of omega-3s are well established in scientific literature. The heavy skewing of polyunsaturated fats toward omega-6 in relation to omega-3 in the modern Western diet is a contributing factor that exacerbates many chronic conditions regularly seen in clinical practice. With docosahexaenoic acid (DHA) serving as a structural component of cell membranes—particularly in the brain—and also recognized as a precursor to inflammation-resolving molecules, sufficient intake of DHA via marine foods or supplements can have far-ranging effects. Obvious and well-documented benefits from DHA are conditions involving inflammation, chronic pain, and ocular health. However, recent research is bringing to light new potential for this fatty acid.

A promising study in rats demonstrated that DHA may minimize neuronal damage due to traumatic brain injury (TBI). Researchers gave test animals DHA doses equivalent to 3, 12, and 40mg/kg for 30 days before inducing TBI. They observed that DHA at the highest dose resulted in positive changes to all markers of axonal and cellular injury studied. Lower doses had more selective effects on individual markers, but were still beneficial. The same researchers had also shown that omega-3 supplements can be helpful for repair following a TBI, but the former study is one of the first to suggest that DHA might actually have prophylactic effects when serum levels are replete prior to injury. Considering how devastating the physical, emotional, and financial effects of TBI can be for the military’s ‘wounded warriors’ and their families, researchers have suggested the Department of Defense prioritize research into regular supplementation with omega-3 fatty acids to establish a protective baseline for those at greatest risk for TBI. The same beneficial effects could also be expected to carry over to others at risk for head injuries, such as young athletes engaged in contact sports.

Another expanding role for DHA is in sleep quality. In a study from Oxford University, children ages 7-9 who were given a 600mg DHA supplement (from algae) for 16 weeks slept close to one hour longer than children taking a placebo. They also had fewer episodes of waking during the night, which could positively impact learning and academic performance. The authors suggest this could be because omega-3 status—especially DHA—seems to influence melatonin production and pineal gland function.   

DHA repletion has also been shown to benefit learning and behavior in children. This makes sense, given DHA’s key role in the physical structure of the brain, but in light of the newer research, perhaps it’s also the result of improved sleep quality. Although the study subjects were children, most adults are only too aware that insufficient sleep makes it difficult to focus and retain new information.  Children given 600mg DHA/day showed improvement in reading ability as measured on standardized tests, and improvement in behavior (attention, impulsivity, opposition, hyperactivity) as rated by parents.