These articles explore the body, the mind, the environment, and the systems that shape human health. Each piece is written to make complex ideas easier to understand, whether the topic is training, nutrition, sleep, stress, digestion, symptoms, physiology, disease, or the way modern life affects how we feel and function.
Strength, Health, & the Art of Living Well
More sleep can double your testosterone
Older men can sometimes double their testosterone levels by getting more sleep, according to a human study that Plamen Penev of the University of Chicago published in Sleep.
More sleep can double your testosterone level
Older men can sometimes double their testosterone levels by getting more sleep, according to a human study that Plamen Penev of the University of Chicago published in Sleep.
Not enough sleep
Nearly all of us probably get too little sleep, mainly because we are seduced every day by the technology around us. It enables us to generate light at night, provides us with 24-hour entertainment and information through electronic media, and makes it possible for us to have contact with each other whenever we want. Every evening, when our body tells us that it's time to sleep, we can also do a thousand other things instead.
Sleep & hormones
Too little sleep messes up our hormone balance. It makes our body less sensitive to insulin for example. Dutch researchers recently showed that after just one night of four hours' sleep, young men's insulin sensitivity went down by twenty percent [J Clin Endocrinol Metab. 2010 Jun;95(6):2963-8.] and that of diabetics by a quarter. [Diabetes Care. 2010 Jul;33(7):1573-7.]
In the latter case, lack of sleep is clinically relevant, so doctors could advise diabetics who react insufficiently to their medicines to get more sleep. "Sleep duration might become another therapeutic target to improve glucoregulation in type 1 diabetes", the Dutch researchers say.
Sleep & testosterone
Testosterone is also affected by amount of sleep. That's not so strange, as our bodies make much more testosterone when they're asleep than when they're awake. [J Clin Endocrinol Metab. 2005 Aug;90(8):4530-5.] The figure below is from the study mentioned here. It shows how much testosterone is present in the blood of 22-32 year-old men while asleep and during the rest of the day.
The better men sleep, the higher their testosterone level rises while they are asleep. [J Clin Endocrinol Metab. 2001 Mar;86(3):1134-9.]
In the average male over forty, the testosterone level goes down by 1-2 percent per year, but researchers occasionally come across men in their eighties with a testosterone level you'd expect in a young man. Add to that the fact that many older men – but not all men – sleep less and less deeply as they get older, then you automatically think of the idea that Plamen Penev wanted to test in his study: does the testosterone level decrease in older men because they sleep less?
Penev based his theory on, among other things, research done by Eve Van Cauter, a sleep researcher at the University of Chicago who has celebrity status in the field of endocrinology. Van Cauter discovered early in the 21st century that men in their forties make less testosterone while sleeping than men in their twenties.[J Clin Endocrinol Metab. 2003 Jul;88(7):3160-6.]
Study
Penev measured the amount of testosterone 12 slim, healthy, non-smoking men aged between 64 and 74 had in their blood in the morning. He also got the men to wear a small gadget around their wrist, which enabled him to see how many hours per night the men slept. That varied from 4.5 to 7.5 per 24 hours. The longer the men slept, the figures below show, the more testosterone there was circulating in their blood.
The men that slept the least had a testosterone level of 200-300 ng/dl. That's a normal amount for men of this age, but it's on the low side. The men in the study who slept the most had a testosterone level that was twice as high: 500-700 ng/dl. That's a level you'd expect in healthy young men.
Conclusion
"These findings suggest that complaints of poor or insufficient sleep in otherwise healthy older men can be associated with a more pronounced age-related androgen decline", writes Penev. "Eliciting such sleep complaints in the physician's office may facilitate the judicious interpretation of lower testosterone levels in the older male patient."
Before men consider doing testosterone therapy, they might first measure the amount of sleep they get. And 'measuring' is different from 'guessing' or 'estimating'. Most people overestimate the number of hours that they sleep. This was also the case in Penev's study. The men thought that they slept seven and a quarter hours per day on average, but Penev's recordings showed that they only slept six hours a day.
Reference: Sleep. 2007 Apr;30(4):427-32.
Hormones and Chronic Stress
Underlying Causes of Adrenal/Hormone Problems
Unhealthy lifestyle habits (poor diet, inadequate exercise, insufficient sleep, lack of relaxation, and internalizing emotional stress) are sources of chronic stress that may be underlying causes of adrenal fatigue and hormone imbalance. Other common sources of chronic stress include: food sensitivities, heavy metals, environmental toxins, radiation exposure, and regular use of prescription drugs. Chronic stress slowly erodes health and compromises longevity.
Under chronic stress, the adrenal glands increase their output of cortisol—often referred to as the “stress hormone.” The principal hormones produced by the adrenal glands—cortisol, DHEA, aldosterone, testosterone, estrogens, and progesterone—share a common precursor, the master hormone pregnenolone. When under stress, the adrenal glands are hyperstimulated and pregnenolone is diverted (stolen) from other pathways to produce cortisol.
Pregnenolone Steal
This increase in the production of cortisol (and the resulting diversion ofpregnenolone) causes fatigue and the general aches and pains associated with chronic stress. However, with time, pregnenolone steal has a much broader damaging effect on health. It exacerbates any developing or existing health problems because pregnenolone is not being adequately converted to other essential hormones. Refer to the following chart to see the dynamic of pregnenolone steal:
What stresses have become chronic, causing the body to divert pregnenolone to provide for the production of cortisol? The sooner you identify and deal with the offenders, the sooner you restore your patients’ health. Consider the following sources as a logical starting point:
- Lifestyle: Diet, Sleep, Exercise, Mental
- Environmental: Pathogen infections, chemicals, heavy metals, food sensitivities, mold, radiation.